Angioedema of the Periorbital Region that Developed during Treatment with Etanercept in a Case of Refractory Adult-Onset Still's Disease
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- Kato Takashi
- Department of Internal Medicine, Omaezaki Municipal General Hospital, Japan
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- Noguchi Kei
- Department of Ophthalmology, Omaezaki Municipal General Hospital, Japan
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- Uehara Masahiro
- Department of Internal Medicine, Omaezaki Municipal General Hospital, Japan
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- Nobuhara Mamoru
- Department of Internal Medicine, Omaezaki Municipal General Hospital, Japan
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- Takahashi Satoru
- Department of Internal Medicine, Omaezaki Municipal General Hospital, Japan
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- Kisamori Yumi
- Department of Internal Medicine, Omaezaki Municipal General Hospital, Japan
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- Ikegaya Hideki
- Department of Internal Medicine, Omaezaki Municipal General Hospital, Japan
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- Ogawa Noriyoshi
- Division of Rheumatology, Department of the Third Internal Medicine, Hamamatsu University School of Medicine, Japan
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- Ohashi Hiroyuki
- Department of Internal Medicine, Omaezaki Municipal General Hospital, Japan
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抄録
A 78-year-old Japanese man with adult-onset Still's disease that was refractory to conventional treatment, such as prednisolone (PSL) concomitant with methotrexate (MTX). Etanercept (50 mg/week) was added to PSL (12.5 mg/day) and MTX (12 mg/week). His manifestation improved dramatically, nonetheless massive edema of the periorbital region developed by the fourth injection, which kept his palpebral fissure completely closed. There was also a marked injection site reaction to etanercept. A diagnosis of angioedema due to etanercept was thus made, and the drug was discontinued. His angioedema began to ameliorate soon after antihistamines were introduced without any critical involvement, such as laryngeal obstruction.<br>
収録刊行物
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- Internal Medicine
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Internal Medicine 51 (19), 2801-2804, 2012
一般社団法人 日本内科学会