Somatic Instability of CTG Expansion in Cancer Tissue?

DOI DOI Web Site Web Site Web Site View 2 Remaining Hide 4 Citations 41 References Open Access
  • ABE Koji
    Department of Neurology, Graduate School of Medicine and Dentistry, Okayama University

Bibliographic Information

Other Title
  • A Patient with Myotonic Dystrophy Type 1(DM1) Accompanied by Laryngeal and Renal Cell Carcinomas Had a Small CTG Triplet Repeat Expansion But No Somatic Instability in Normal Tissues
  • Patient with Myotonic Dystrophy Type 1 DM1 Accompanied by Laryngeal and Renal Cell Carcinomas Had a Small CTG Triplet Repeat Expansion But No Somatic Instability in Normal Tissues

Search this article

Description

We examined (CTG)n lengths in various tissues from a 70-year-old man with myotonic dystrophy type 1 (DM1) who had a small 60-70 (CTG)n expansion in his leukocytes. He died of renal cell carcinoma 5 years after a total laryngectomy for laryngeal carcinoma. Southern blot and polymerase chain reaction analyses were done on tissues obtained at autopsy. In the various normal tissues, (CTG)n lengths were almost all the same size, whereas the renal cell carcinoma and metastatic tissues had longer lengths. When compared with the lengths in leukocytes about 5 years previously, (CTG)n lengths in the normal tissues were the same size. These findings suggest that both somatic instability and age-dependent (CTG)n expansion in DM1 patients with a small expansion may be less dominant than in patients with large expansions.<br>(Internal Medicine 41: 312-318, 2002)

Journal

  • Internal Medicine

    Internal Medicine 41 (4), 253-253, 2002

    The Japanese Society of Internal Medicine

Citations (4)*help

See more

References(41)*help

See more

Keywords

Details 詳細情報について

Report a problem

Back to top