Identification of Clinical Phenotypes in Idiopathic Interstitial Pneumonia with Pulmonary Emphysema
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- Sato Suguru
- Department of Pulmonary Medicine, Fukushima Medical University School of Medicine, Japan
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- Tanino Yoshinori
- Department of Pulmonary Medicine, Fukushima Medical University School of Medicine, Japan
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- Misa Kenichi
- Department of Pulmonary Medicine, Fukushima Medical University School of Medicine, Japan
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- Fukuhara Naoko
- Department of Pulmonary Medicine, Fukushima Medical University School of Medicine, Japan
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- Nikaido Takefumi
- Department of Pulmonary Medicine, Fukushima Medical University School of Medicine, Japan
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- Uematsu Manabu
- Department of Pulmonary Medicine, Fukushima Medical University School of Medicine, Japan
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- Fukuhara Atsuro
- Department of Pulmonary Medicine, Fukushima Medical University School of Medicine, Japan
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- Wang Xintao
- Department of Pulmonary Medicine, Fukushima Medical University School of Medicine, Japan
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- Ishida Takashi
- Department of Pulmonary Medicine, Fukushima Medical University School of Medicine, Japan
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- Munakata Mitsuru
- Department of Pulmonary Medicine, Fukushima Medical University School of Medicine, Japan
説明
Objective Since the term "combined pulmonary fibrosis and emphysema" (CPFE) was first proposed, the co-existence of pulmonary fibrosis and pulmonary emphysema (PE) has drawn considerable attention. However, conflicting results on the clinical characteristics of patients with both pulmonary fibrosis and PE have been published because of the lack of an exact definition of CPFE. The goal of this study was thus to clarify the clinical characteristics and phenotypes of idiopathic interstitial pneumonia (IIP) with PE. Methods We retrospectively analyzed IIP patients who had been admitted to our hospital. Their chest high-resolution computed tomography images were classified into two groups according to the presence of PE. We then performed a cluster analysis to identify the phenotypes of IIP patients with PE. Results Forty-four (53.7%) out of 82 patients had at least mild emphysema in their bilateral lungs. The cluster analysis separated the IIP patients with PE into three clusters. The overall survival rate of one cluster that consisted of mainly idiopathic pulmonary fibrosis (IPF) patients was significantly worse than those of the other clusters. Conclusion Three different phenotypes can be identified in IIP patients with PE, and IPF with PE is a distinct clinical phenotype with a poor prognosis.
収録刊行物
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- Internal Medicine
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Internal Medicine 55 (12), 1529-1535, 2016
一般社団法人 日本内科学会