Acquired Factor V Inhibitors in a Patient with End-stage Renal Disease
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- Kitazawa Atsushi
- Nephrology, Dokkyo Medical University Koshigaya Hospital, Japan
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- Misawa Hideo
- Nephrology, Dokkyo Medical University Koshigaya Hospital, Japan
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- Nagahori Katsuhiro
- Nephrology, Dokkyo Medical University Koshigaya Hospital, Japan
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- Koda Ryo
- Nephrology, Dokkyo Medical University Koshigaya Hospital, Japan
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- Yoshino Atsunori
- Nephrology, Dokkyo Medical University Koshigaya Hospital, Japan
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- Kawamoto Shinya
- Nephrology, Dokkyo Medical University Koshigaya Hospital, Japan
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- Takeda Tetsuro
- Nephrology, Dokkyo Medical University Koshigaya Hospital, Japan
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説明
<p>We report a case of acquired factor V inhibitors (AFVIs) in a patient with end-stage renal disease receiving warfarin therapy for atrial fibrillation. A 72-year-old Japanese man was admitted to our hospital complaining of tarry stools and abdominal pain. The laboratory findings revealed eosinophilia (52.1%), prolonged activated partial thromboplastin time (APTT) (98 s), PT (84 s), a factor V (FV) activity of <3%, and an FV inhibitor level of 6 Bethesda units/mL. After administration of prednisolone was started, his coagulation findings improved. However, his renal failure progressed, and he ultimately required chronic hemodialysis. This is the first case of AFVIs in a patient starting hemodialysis for end-stage renal disease. </p>
収録刊行物
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- Internal Medicine
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Internal Medicine 55 (23), 3505-3509, 2016
一般社団法人 日本内科学会
