Clinical Features, Pathogenesis, and Treatment of Large Granular Lymphocyte Leukemias
-
- Oshimi Kazuo
- Department of Medicine, Kushiro Rosai Hospital, Japan
この論文をさがす
説明
<p>Large granular lymphocytes (LGLs) are large lymphocytes with azurophilic granules in their cytoplasm. LGLs are either natural killer (NK) cells or T lymphocytes. Expansions of the LGLs in the peripheral blood are seen in various conditions, including three clonal disorders: T-cell LGL (T-LGL) leukemia, chronic lymphoproliferative disorders of NK cells (CLPD-NK), and aggressive NK-cell leukemia (ANKL). However, the monoclonal and polyclonal expansion of LGLs has been associated with many other conditions. The present article describes these LGL disorders, with special emphasis on the clinical features, pathogenesis, and treatments of the three above-mentioned clonal disorders. </p>
収録刊行物
-
- Internal Medicine
-
Internal Medicine 56 (14), 1759-1769, 2017
一般社団法人 日本内科学会
