Beneficial Effects of Ramelteon on Rapid Eye Movement Sleep Behavior Disorder Associated with Parkinson's Disease - Results of a Multicenter Open Trial

  • Kashihara Kenichi
    Department of Neurology, Okayama Kyokuto Hospital, Japan
  • Nomura Takashi
    Division of Neurology, Department of Brain and Neurosciences, Faculty of Medicine, Tottori University, Japan
  • Maeda Tetsuya
    Department of Neurology and Movement Disorder Research, Research Institute for Brain and Blood Vessels-Akita, Japan
  • Tsuboi Yoshio
    Department of Neurology, Faculty of Medicine, Fukuoka University, Japan
  • Mishima Takayasu
    Division of Neurology, Department of Brain and Neurosciences, Faculty of Medicine, Tottori University, Japan
  • Takigawa Hiroshi
    Division of Neurology, Department of Brain and Neurosciences, Faculty of Medicine, Tottori University, Japan
  • Nakashima Kenji
    Division of Neurology, Department of Brain and Neurosciences, Faculty of Medicine, Tottori University, Japan

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Other Title
  • Beneficial effects of ramelteon on rapid eye movement sleep behavior disorder associated with Parkinson’s disease—Results of a multicenter open trial

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Abstract

Objective Melatonin is effective for treating patients with rapid eye movement sleep behavior disorder (RBD). Ramelteon, a novel hypnotic, acts as a melatonin receptor agonist. In the current study, we investigated the effects of ramelteon on sleep disorders, including RBD, in patients with Parkinson's disease (PD).<br> Methods We evaluated 35 patients from multiple centers with idiopathic PD accompanied by sleep disturbances (age: 69.1±11.1 years; 17 men, 18 women; PD morbidity: 6.9±5.7 years; Hoehn & Yahr stage: 2.5±0.8; levodopa dose equivalent: 561±401 mg/day). The patients received 8 mg of ramelteon before sleep once daily for 12 weeks. Motor and sleep symptoms were evaluated both before and after ramelteon administration.<br> Results Of the 35 patients enrolled in this study, 24 (68.6%) were diagnosed with probable RBD (pRBD) using the Japanese version of the RBD screening questionnaire. Ramelteon administration reduced the severity of sleep disturbances in patients with PD. It also lowered scores on the Japanese version of the RBD questionnaire in patients with PD and pRBD.<br> Conclusion Ramelteon may have beneficial effects on sleep disturbances, especially on RBD in patients with PD.<br>

Journal

  • Internal Medicine

    Internal Medicine 55 (3), 231-236, 2016

    The Japanese Society of Internal Medicine

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