Studies on serum complement in liver diseases

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  • Sudo Chizuko
    The 1st Department of Internal Medicine Okayama University Medical School

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Other Title
  • 肝疾患における血清補体に関する研究
  • 血清補体価と臨床経過との関連
  • ケッセイホタイカ ト リンショウ ケイカ ト ノ カンレン
  • 第一編 血清補体価と臨床経過との関連
  • Report 1 Reference to serum complement activity and clinical features

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Serum complement levels in 200 patients with hepatic disorders or jaundice were determined in succesion by the 50% hemolysis method of Mayer.<br>The following results were obtained.<br>1) In cases of acute hepatitis, serum complement levels (CH50) were high during 12 weeks after the onset and gradually returned to normal range in 4 weeks with the improvement of clinical symptoms. While, CH50 levels in acute persistent hepatitis showed a slightly elevated value over 8 weeks after the onset of illness and fluctuated with exacerbations.<br>2) In cases of chronic hepatitis, CH50 levels at the stage of remission remained in normal range and showed an indefinit fluctuation by relapsing.<br>3) CH50 levels in liver cirrhosis were low and in some cases unable to be estimated and with exacerbations became lower gradually.<br>4) In cases of drug induced (toxic) hepatitis, CH50 levels showed an markedly elevated value and remained high during a few weeks after jaundice had faded.<br>5) In cases of intrahepatic cholestasis with persistent jaundice, CH50 levels were high and correlated well with serum bilirubin variation.<br>6) It wes observed that CH50 levels showed a tendency to decrease in cases of chronic hepatitis and liver cirrhosis in which serum γ-globulin increased and RA factor or/and antihepatic antibody appeared.

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