Aging and sensitivity of rat granulation tissue and thymus to glucocorticoids

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  • 加令と肉芽組織ならびに胸腺の糖質コルチコイドに対する感受性
  • カレイ ト ニクガ ソシキ ナラビニ キョウセン ノ トウシツ コルチコイド

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Abstract

Granulomas were induced in rats of both sexes at different weeks of age by subcutaneous implantation of formalin-soaked filter-paper disks. The sensitivity changes with aging to the antigranuloma and thymolytic actions of prednisolone acetate were studied by measuring the dry-defatted weight of granulomas and the wet weight of thymus. The prednisolone acetate effects on these tissues were also investigated by electron microscopy.<br>In male rats, the amount of granulation tissue increased from 6 to 12 weeks of age; but no difference in granuloma weight was evident between the 12- and 20-week-old groups. In females, the granuloma weight also increased form 6 to 8 weeks. However, heavier granulomas were found in males than in females.<br>In both sexes, the 20-week-old group showed lower sensitivity to the antigranuloma and thymolytic actions of prednisolone acetate than the 6- and 8-week-old groups. In the 6-, 8- and 20-week-old groups of both sexes, marked differences were not found between the antigranuloma potency and thymolytic potency of prednisolone acetate.<br>The prednisolone acetate dose required to produce appreciable electron microscopic changes were about the same in granulation tissue and thymus.<br>The present results show that rat granulation tissue and thymus have similar degrees of sensitivity to glucocorticoids and that the sensitivity of these tissues is lowered with aging.

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