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- 近藤 昭
- 岡山大学医学部第2内科教室
書誌事項
- タイトル別名
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- Studies on Patients with Sarcoidosis
- サルコイドージスに関する研究-2-末梢血単球機能の検討
- サルコイドージス ニカンスルケンキュウ 2 マッショウケツ タンキュウ キノウ
- 第2編 末梢血単球機能の検討
- Part II. Monocyte Function in Sarcoidosis Patients
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説明
Functions of peripheral blood monocytes in 13 patients with sarcoidosis were studied and compared to normal individuals.<br>The mean absolute number of monocytes was 277±121/cmm(M±SD) in sarcoidosis patients and 299±144/cmm in controls. However, there was no significant difference between the two groups.<br>Lysosomal enzyme activity of monocytes was histochemically determined by ability of staining to beta-galactosidase. The mean percentage of beta-galactosidase positive monocytes was 35.8±16.9 in sarcoidosis patients and 33.7±12.1 in controls. There was no significant difference between the two groups.<br>Monocyte chemotactic response was measured in vitro by Boyden's millipore technique-using zymosan activated human serum as chemoattractant. Chemotactic response was significantly reduced in sarcoidosis patients (28.2±7.0) compared with controls (34.8±8.0).<br>Ability of monocyte to phagocytize the complement coated zymosan was also significantly lower in sarcoidosis patients (49.2±24.1) compared with controls (84.1±9.4).<br>Monocyte-mediated cytotoxicity was tested by the inhibition of 3H-thymidine uptake by two tumor cell lines. The growth-inhibitory activity was 87.0±8.6 in sarcoidosis patients and 85.5±8.0 in controls using human squamous lung cancer cell line (EBC-1) for the target cell, and 47.5±14.0 and 46.4±11.8 respectively using Hella cell. There was no significant difference between the two groups using either target cell.
収録刊行物
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- 岡山医学会雑誌
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岡山医学会雑誌 94 (5-6), 431-438, 1982
岡山医学会
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詳細情報 詳細情報について
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- CRID
- 1390001204879281408
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- NII論文ID
- 120005816501
- 130006863233
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- NII書誌ID
- AN00032489
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- ISSN
- 18824528
- 00301558
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- NDL書誌ID
- 2492082
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