Relationship between Intraischemic Hypothermia and Postischemic Reperfusion : Relevance to Delayed Neuronal Death

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  • KUBOTA Yasushi
    Department of Anesthesiology, Kyorin University School of Medicine

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  • 前脳虚血中の低脳温と再潅流時の脳血流量の関連 : 遅発性神経細胞死との関係

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Abstract

Intraischemic hypothermia is a major protective factor against delayed neuronal death after global ischemia. The relationship between the brain temperature and reperfusion status were examined. Twenty-one Mongolian gerbils were anesthetized with halothane. Epidural brain temperature and cortical blood flow measured by using Laser-Doppler flowmetry were monitored through a cranial window before and after ischemia. Forebrain ischemia was induced by ligation of both carotid arteries for 5 min. The brains were perfusion-fixed after seven-days reperfusion. There was a significant correlation (p<0.05) between the intraischemic brain temperature and the pyramidal cell density of CA-1 sector in the hippocampus. The features of blood flow during reperfusion were classified into two types. Intraischemic hypothermic group showed hyperdynamic pattern, whereas other normothermia group showed hypodynamic pattern. In conclusion, intraischemic hypothermia relates to hyperdynamic pattern of reperfusion, resulting in less damage in CA-1 pyramidal cells in the hippocampus.

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