A dosage nomogram for trimetaphan to control the blood pressure during ketamine anesthesia

DOI Web Site
  • HONJO Shigeru
    Department of anesthesiology, Kyorin University School of Medicine
  • HIMURO Hiroto
    Department of anesthesiology, Kyorin University School of Medicine
  • KAMIYAMA Morito
    Department of anesthesiology, Kyorin University School of Medicine

Bibliographic Information

Other Title
  • トリメトファン希薄液微量点滴法の臨床的検討 : ケタミン麻酔時の血圧制御を中心に
  • トリメトファン キハクエキ ビリョウ テンテキホウ ノ リンショウテキ ケント

Search this article

Abstract

Trimetaphan was used to control the blood pressure in 38 patients varying in age from 5-81 years under ketamine, pentazocine & diazepam micro drip infusion or NLA. Blood pressure were obtained with the usual Riva-Rocci sphygmomanometer and recorded every five minute during surgery. Systolic blood pressure was reduced with a rate of less than -Δ3mmHg/min by infusing 0.01-0.025% solution of trimetaphan in vactated Ringer's solution. Blood pressure was maintained to a resting level during anesthesia. An inverse relationship was found between patient age and minute dosage of trimetaphan-induction dosage, and also the minute dosage of maintenance. Previously trimetaphan dosage and concentration was adjusted according to recommended dosage raning from 500-1000 μg/ml. But to eliminate excessive hypotension and other dangerous complication, and to attain consistently safe levels of blood pressure in aged patients, infusion of diluted trimetaphan solution (100-200 μg/ml) has been proved to be very useful.

Journal

Details 詳細情報について

Report a problem

Back to top