The Action of Serotonin on the Self-recurrent Synaptic Transmission in the Cultured Rat Hippocampal Neuron

DOI 3 Citations 25 References
  • KOGURE Miki
    Department of Neuropsychiatry, Course of Internal Medicine (Doctor's Program), Kyorin University

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  • 海馬培養神経細胞の自己回帰性シナプス伝達におけるSerotoninの作用

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The action of serotonin (5-HT) on the self-recurrent synaptic (autaptic) transmission in the culturedrat hippocampal neuron was studied by the whole-cell patch-clamp methods. Bath application of 5-HT (10 μM) decreased amplitude of the autapticepsc, and 8-OH-DPAT caused the similar effects. These effects were suggested to be mediated through 5-HT_<1A> receptor. Distribution pattern of the amplitudes of asynchronous epsc, which appeared just after the evoked epsc, was not affected by 5-HT, suggesting that 5-HT acted on the pre-synaptic terminal and decreased the release of the excitatory neuro-transmitter.

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