Amino acid residues conferring the nucleotide binding properties of N-acetyl-D-glucosamine 2-epimerase (renin binding protein)

  • TAKAHASHI Saori
    Department of Bioengineering, Akita Research Institute of Food and Brewing (ARIF)
  • OGASAWARA Hironobu
    Department of Bioengineering, Akita Research Institute of Food and Brewing (ARIF)
  • HIWATASHI Kazuyuki
    Department of Bioengineering, Akita Research Institute of Food and Brewing (ARIF)
  • HATA Keishi
    Department of Bioengineering, Akita Research Institute of Food and Brewing (ARIF)
  • HORI Kazuyuki
    Department of Bioengineering, Akita Research Institute of Food and Brewing (ARIF)
  • KOIZUMI Yukio
    Department of Biochemistry, School of Medicine, Akita University
  • SUGIYAMA Toshihiro
    Department of Biochemistry, School of Medicine, Akita University

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説明

Our recent studies have demonstrated that the middle domain of N-acetyl-D-glucosamine (GlcNAc) 2-epimerase participates in the specificity for and binding of nucleotides. To identify the residue conferring nucleotide binding, amino acid substitutions were introduced in the human and rat GlcNAc 2-epimerases. The mutational analyses indicate that residue 171 of GlcNAc 2-epimerase is critical for the nucleotide binding of GlcNAc 2-epimerase.

収録刊行物

  • Biomedical Research

    Biomedical Research 26 (3), 117-121, 2005

    バイオメディカルリサーチプレス

被引用文献 (3)*注記

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参考文献 (18)*注記

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詳細情報 詳細情報について

  • CRID
    1390001204901734784
  • NII論文ID
    130004470640
    80017436066
  • DOI
    10.2220/biomedres.26.117
  • COI
    1:CAS:528:DC%2BD2MXmtVeitbY%3D
  • ISSN
    1880313X
    03886107
  • PubMed
    16011304
  • Web Site
    https://search.jamas.or.jp/link/ui/2006193285
  • 本文言語コード
    en
  • 資料種別
    journal article
  • データソース種別
    • JaLC
    • Crossref
    • PubMed
    • CiNii Articles
    • OpenAIRE
  • 抄録ライセンスフラグ
    使用不可

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