Amino acid residues conferring the nucleotide binding properties of N-acetyl-D-glucosamine 2-epimerase (renin binding protein)
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- TAKAHASHI Saori
- Department of Bioengineering, Akita Research Institute of Food and Brewing (ARIF)
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- OGASAWARA Hironobu
- Department of Bioengineering, Akita Research Institute of Food and Brewing (ARIF)
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- HIWATASHI Kazuyuki
- Department of Bioengineering, Akita Research Institute of Food and Brewing (ARIF)
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- HATA Keishi
- Department of Bioengineering, Akita Research Institute of Food and Brewing (ARIF)
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- HORI Kazuyuki
- Department of Bioengineering, Akita Research Institute of Food and Brewing (ARIF)
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- KOIZUMI Yukio
- Department of Biochemistry, School of Medicine, Akita University
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- SUGIYAMA Toshihiro
- Department of Biochemistry, School of Medicine, Akita University
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説明
Our recent studies have demonstrated that the middle domain of N-acetyl-D-glucosamine (GlcNAc) 2-epimerase participates in the specificity for and binding of nucleotides. To identify the residue conferring nucleotide binding, amino acid substitutions were introduced in the human and rat GlcNAc 2-epimerases. The mutational analyses indicate that residue 171 of GlcNAc 2-epimerase is critical for the nucleotide binding of GlcNAc 2-epimerase.
収録刊行物
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- Biomedical Research
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Biomedical Research 26 (3), 117-121, 2005
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