EFFECTS OF L-GLUTAMINE, METHYLMETHIONINE-SULFONIUM CHLORIDE (MMSCI), ANTACIDS OR THEIR COMBINATION ON THE DEVELOPMENT OR HEALING OF EXPERIMENTAL GASTRIC OR DUODENAL ULCER IN THE RATS

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  • 実験的胃・十二指腸潰瘍に対するL-glutamine, methylmethionine sulfonium chlorideおよび制酸剤の併用効果

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Effects of orally given L-glutamine, MMSC1, antacids (magnesium aluminosilicate·CaCO3) or their combination on various experimental gastric or duodenal ulcer and gastric secretion in rats were studied. 1. L-Glutamine at 1, 284mg/kg or MMSCI at 80mg/kg did not inhibit the stress ulcer induced by water-immersion stress (25°C, 20hr), while antacids at 1, 636mg/kg showed a tendency for inhibition of the ulcer. The combination significantly inhibited the development of the ulceration and resulted in a potentiation of the effect caused by each drug alone. 2. L-Glutamine at 427.8mg/kg, MMSCI at 26.7mg/kg or antacids at 545.5mg/kg did not inhibit Shay ulcer (48hr fasting, 12hr ligation). The combination significantly inhibited the ulcer and resulted in a potentiation of the effect caused by each drug, at which time the gastric acidity and the pepsin activity were significantly reduced. 3. L-Glutamine at 427.8mg/kg or antacids at 545.5mg/kg did not inhibit the development of the gastric lesions induced by noradrenaline and serotonin (4hr), while MMSCI at 26.7mg/kg showed inhibition of the ulcer. The combination markedly inhibited the ulcer and resulted in a potentiation of the effect caused by each drug alone. 4. L-Glutamine at 427.8mg/kg inhibited the development of the gastric lesions induced by aspirin in pylorus-ligated animals (7hr), while MMSCI at 26.7mg/kg or antacids at 545.5mg/kg did not inhibit the ulcer at all. The combination markedly inhibited the ulcer and resulted in a potentiation of the effect caused by each drug alone. 5. Consecutive administration of L-glutamine (855.6mg/kg/day), MMSCI (53.4mg/kg/day) or antacids (1, 019mg/kg/day) for 10 days after ulcerative operation showed a significant effect for the healing of gastric ulcer. The combination revealed a significant effect but not d potentiation of the effect caused by each drug alone. 6. Consecutive administration of L-glutamine (427.8mg/kg/day), MMSCI (26.7mg/kg/day) or antacids (545.5mg/kg/day) for 10 days failed to affect the healing of duodenal ulcer, whereas the combination revealed a significant acceleration of the healing and resulted in a potentiation of the effect caused by each drug alone. The dosing by L-glutamine (855.6mg/kg/day), MMSCI (53.4mg/kg/day) or antacids (1, 019mg/kg/day) showed a significant effect for the healing.

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