Effect of plantar subcutaneous administration of bergamot essential oil and linalool on formalin-induced nociceptive behavior in mice

DOI HANDLE PubMed 被引用文献10件 参考文献29件 オープンアクセス
  • KATSUYAMA Soh
    Department of Clinical Pharmaceutics, Tohoku Pharmaceutical University
  • OTOWA Akira
    Department of Clinical Pharmaceutics, Tohoku Pharmaceutical University
  • KAMIO Satomi
    Department of Clinical Pharmaceutics, Tohoku Pharmaceutical University
  • SATO Kazuma
    Department of Clinical Pharmaceutics, Tohoku Pharmaceutical University
  • YAGI Tomomi
    Department of Clinical Pharmaceutics, Tohoku Pharmaceutical University
  • KISHIKAWA Yukinaga
    Department of Clinical Pharmaceutics, Tohoku Pharmaceutical University
  • KOMATSU Takaaki
    Department of Pharmacology, Daiichi College of Pharmaceutical Sciences
  • BAGETTA Giacinto
    Department of Pharmacobiology and University Consortium for Adaptive Disorders and Headache, Section of Neuropharmacology of Normal and Pathological Neuronal Plasticity, University of Calabria
  • SAKURADA Tsukasa
    Department of Pharmacology, Daiichi College of Pharmaceutical Sciences
  • NAKAMURA Hitoshi
    Department of Clinical Pharmaceutics, Tohoku Pharmaceutical University

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タイトル別名
  • <b>Effect of plantar subcutaneous administration of bergamot essential oil and linalool on formalin-induced nociceptive behavior in </b><b>mice </b>

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説明

This study investigated the effect of bergamot essential oil (BEO) or linalool, a major volatile component of BEO, on the nociceptive response to formalin. Plantar subcutaneous injection of BEO or linalool into the ipsilateral hindpaw reduced both the first and late phases of the formalininduced licking and biting responses in mice. Plantar subcutaneous injection of BEO or linalool into the contralateral hindpaw did not yield an antinociceptive effect, suggesting that the antinociceptive effect of BEO or linalool in the formalin test occurred peripherally. Intraperitoneal and plantar subcutaneous injection pretreatment with naloxone hydrochloride, an opioid receptor antagonist, significantly attenuated both BEO- and linalool-induced antinociception. Pretreatment with naloxone methiodide, a peripherally acting opioid receptor antagonists, also significantly antagonized the antinociceptive effects of BEO and linalool. Our results provide evidence for the involvement of peripheral opioids in antinociception induced by BEO and linalool. These results suggest that activation of peripheral opioid receptors may play an important role in reducing formalin-induced nociception.

収録刊行物

  • Biomedical Research

    Biomedical Research 36 (1), 47-54, 2015

    バイオメディカルリサーチプレス

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