Coagulation Factors in Type 2 Diabetes Mellitus: Association with Nephropathy.

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  • Kubo Keiji
    Department of Endocrinology, Hiroshima Prefectural Hospital

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  • ２型糖尿病患者における血液凝固因子の検討　　腎症との関連性について
  • 2ガタ トウニョウビョウ カンジャ ニ オケル ケツエキ ギョウコ インシ ノ ケントウ : ジンショウ ト ノ カンレンセイ ニ ツイテ
  • Association with Nephropathy
  • 腎症との関連性について

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Abstract

To assess the relationship between diabetic nephropathy and coagulation factors, we divided 73 patients with type 2 diabetes mellitus into 3 groups-normoalbuminuria [normo] with urinary albumin excretion [UAE]<30mg/day, microalbuminuria [micro] with [UAE] from 30-300, and macroalbuminuria [macro] with [UAE]>300. Their D dimer, prothrombin fragments F 1+2 (F 1+2), and fibrinogen were measured. D dimer was significantly higher in the micro group than in the normo group, and was significantly higher in the macro group than in the micro group. F 1+2 was significantly higher in the micro and macro groups than in the normo group. Fibrinogen was significantly higher in the macro group than in the normo and micro groups. Thrombin activation may occur from the early stages of diabetic nephropathy, and may progress as nephropathy progresses.

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