犬におけるインスリン低血糖に対するグルカゴン皮下注の効果

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書誌事項

タイトル別名
  • Effect of Glucagon on Insulin-induced Hypoglycemia in Dogs
  • イヌ ニ オケル インスリン テイ ケットウ ニ タイスル グルカゴン ヒ シ

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抄録

The hyperglycemic effect of glucagon has been established, but its effect on hypoglycemia in animals has been scarcely reported. We examined the effect of glucagon on insulin-induced hypoglycemia with various injection times in dogs. We aimed at obtaining information on the clinical application of glucagon in the hypoglycemic state.<BR>Blood sugar levels were measured serially after subcutaneous injection of insulin (Actrapid, 0.4U/kg) with and without subsequent glucagon administration (10μg/kg, subcutaneously) at 15, 30 or 90 min. after the insulin injection.<BR>In cases where glucagon was administered at 15 min. or at 30 min. after the insulin injection, blood sugar levels increased significantly, even though temporarily, as compared to those in the control dogs which received the single insulin injection.<BR>On the other hand, when glucagon was injected at 90 min. after the injection of insulin, blood sugar levels were significantly higher than in the control at 15-60 min. after glucagon injection.<BR>Moreover, blood sugar peak levels at 30 and 45 min. after glucagon injection were very high, and increased 10 per cent more than normal levels. It was assumed that glycogen synthetase was activated by the pre-injected insulin, leading to increased glycogen synthesis which might thus account for the sustained hyperglycemia induced by glucagon in this series.<BR>It was concluded that glucagon must be administered carefully taking the injection time into consideration on insulin-induced hypoglycemia in clinical use because of its effect in response to the glycogen contents in liver.

収録刊行物

  • 糖尿病

    糖尿病 20 (6), 748-752, 1977

    一般社団法人 日本糖尿病学会

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