Fluoride-induced iron overload contributes to hepatic oxidative damage in mouse and the protective role of Grape seed proanthocyanidin extract

DOI Web Site Web Site PubMed 参考文献30件
  • Niu Qiang
    Department of Public Health, Medical College, Shihezi University, China
  • He Ping
    Occupational disease prevention and control of hospital of the Xinjiang Uygur Autonomous Region, China
  • Xu Shangzhi
    Department of Public Health, Medical College, Shihezi University, China
  • Ma Ruling
    Department of Public Health, Medical College, Shihezi University, China
  • Ding Yusong
    Department of Public Health, Medical College, Shihezi University, China
  • Mu Lati
    Department of Public Health, Medical College, Shihezi University, China
  • Li Shugang
    Department of Public Health, Medical College, Shihezi University, China

この論文をさがす

抄録

<p>Emerging evidence has demonstrated that iron overload plays an important role in oxidative stress in the liver. This study aimed to explore whether fluoride-induced hepatic oxidative stress is associated with iron overload and whether grape seed proanthocyanidin extract (GSPE) alleviates oxidative stress by reducing iron overload. Forty Kunming male mice were randomly divided into 4 groups and treated for 5 weeks with distilled water (control), sodium fluoride (NaF) (100 mg/L), GSPE (400 mg/kg bw), or NaF (100 mg/L) + GSPE (400 mg/kg bw). Mice exposed to NaF showed typical poisoning changes of morphology, increased aspartate aminotransferase and alanine aminotransferase activities in the liver. NaF treatment also increased MDA accumulation, decreased GSH-Px, SOD and T-AOC levels in liver, indicative of oxidative stress. Intriguingly, all these detrimental effects were alleviated by GSPE. Further study revealed that NaF induced disorders of iron metabolism, as manifested by elevated iron level with increased hepcidin but decreased ferroportin expression, which contributed to hepatic oxidative stress. Importantly, the iron dysregulation induced by NaF could be normalized by GSPE. Collectively, these data provide a novel insight into mechanisms underlying fluorosis and highlight the potential of GSPE as a naturally occurring prophylactic treatment for fluoride-induced hepatotoxicity associated with iron overload.</p>

収録刊行物

参考文献 (30)*注記

もっと見る

キーワード

詳細情報 詳細情報について

問題の指摘

ページトップへ