Garcinia vilersiana bark extract activates the Nrf2/HO-1 signaling pathway in RAW264.7 cells

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  • Shinkai Yasuhiro
    Doctoral Program in Biomedical Sciences, Graduate School of Comprehensive Human Sciences, University of Tsukuba Master’s Program in Environmental Sciences, Graduate School of Life and Environmental Sciences, University of Tsukuba
  • Yamanaka Ichiro
    Master’s Program in Environmental Sciences, Graduate School of Life and Environmental Sciences, University of Tsukuba
  • Duong Ho Huynh Thuy
    Department of Genetics, Faculty of Biology, Ho Chi Minh City University of Science, Vietnam
  • Quynh Nguyen Thi
    Department of Plant Cell Technology, Institute of Tropical Biology, Vietnam Academy of Science and Technology, Vietnam
  • Kanaho Yasunori
    Doctoral Program in Biomedical Sciences, Graduate School of Comprehensive Human Sciences, University of Tsukuba
  • Kumagai Yoshito
    Doctoral Program in Biomedical Sciences, Graduate School of Comprehensive Human Sciences, University of Tsukuba Master’s Program in Environmental Sciences, Graduate School of Life and Environmental Sciences, University of Tsukuba

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  • <i>Garcinia vilersiana</i> bark extract activates the Nrf2/HO-1 signaling pathway in RAW264.7 cells

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Garcinia vilersiana is a traditional medicinal plant in Vietnam. The petroleum ether extract of stem bark of Garcinia vilersiana (GVE) was prepared to evaluate its potential to activate Nrf2, a transcription factor of antioxidant and detoxifying enzymes. Exposure of mouse macrophage RAW264.7 cells to GVE (0.625-2.5 µg/ml) resulted in a significant activation of Nrf2, as evaluated by nuclear accumulation of this transcription factor, and increased antioxidant response element (ARE) binding activity in a time- and concentration-dependent manner. As a result, GVE caused ARE-dependent up-regulation of heme oxygenase-1 (HO-1) in the cells. These results suggest that GVE contains components that have the ability to activate the Nrf2/ARE/HO-1 signaling pathway, leading to cellular protection.

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