A Case of Obese Diabetic Woman with Amenorrhea and Hyperandrogenism-Effect of VLCD and LCD Therapy on Gonadal Function-

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  • Kita Atsushi
    Division of Immunology, Endocrinology and Metabolism, Graduate School of Biochemical Sciences, Nagasaki University
  • Yamasaki Hironori
    Division of Immunology, Endocrinology and Metabolism, Graduate School of Biochemical Sciences, Nagasaki University
  • Yamakawa Kennichi
    Division of Immunology, Endocrinology and Metabolism, Graduate School of Biochemical Sciences, Nagasaki University
  • Saigo Shiori
    Division of Immunology, Endocrinology and Metabolism, Graduate School of Biochemical Sciences, Nagasaki University
  • Fukushima Tetsuya
    Division of Immunology, Endocrinology and Metabolism, Graduate School of Biochemical Sciences, Nagasaki University
  • Takahashi Ryoko
    Division of Immunology, Endocrinology and Metabolism, Graduate School of Biochemical Sciences, Nagasaki University
  • Kuwahara Hironaga
    Division of Immunology, Endocrinology and Metabolism, Graduate School of Biochemical Sciences, Nagasaki University
  • Fujita Naruhiro
    Division of Immunology, Endocrinology and Metabolism, Graduate School of Biochemical Sciences, Nagasaki University
  • Miyazoe Haruko
    Division of Immunology, Endocrinology and Metabolism, Graduate School of Biochemical Sciences, Nagasaki University
  • Oshima Katsuya
    Division of Immunology, Endocrinology and Metabolism, Graduate School of Biochemical Sciences, Nagasaki University
  • Abiru Norio
    Unit of Metabolism Diabetes and Clinical Nutrition, Nagasaki University School of Medicine
  • Sakamaki Hiroyuki
    Division of Immunology, Endocrinology and Metabolism, Graduate School of Biochemical Sciences, Nagasaki University
  • Uotani Shigeo
    Division of Immunology, Endocrinology and Metabolism, Graduate School of Biochemical Sciences, Nagasaki University
  • Kawasaki Eiji
    Unit of Metabolism Diabetes and Clinical Nutrition, Nagasaki University School of Medicine
  • Yamaguchi Yoshihiko
    Division of Immunology, Endocrinology and Metabolism, Graduate School of Biochemical Sciences, Nagasaki University
  • Eguchi Katsumi
    Division of Immunology, Endocrinology and Metabolism, Graduate School of Biochemical Sciences, Nagasaki University

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Other Title
  • 無月経，男性化徴候を伴った高度肥満女性患者の１例―ＶＬＣＤおよびＬＣＤ療法の性機能に及ぼす影響―
  • ショウレイ ホウコク ムゲッケイ,ダンセイカ チョウコウ オ トモナッタ コウド ヒマン ジョセイ カンジャ ノ 1レイ : VLCD オヨビ LCD リョウホウ ノ セイ キノウ ニ オヨボス エイキョウ
  • Effect of VLCD and LCD Therapy on Gonadal Function
  • VLCDおよびLCD療法の性機能に及ぼす影響

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Abstract

Obesity is an important causative factor in inducing insulin resistance and affecting gonadal function in women. We studied an obese diabetic woman with amenorrhea and hyperandrogenism such as hypertrichosis and acanthosis nigricans. Very low calorie diet (VLCD) and LCD therapy to this patient resulted in a 21.5 kg weight loss. Visceral fat area analyzed by abdominal CT was redued 48% and insulin resistance improved after VLCD LCD therapy. Elevated testosterone and androstendione serum were normalized from 89.0 to 21.6ng/dl and 3.5 to 1.1ng/ml. As reflected by sexual hormone ameriolation, her hypertrichosis and acanthosis nigricans almost disappeared 7 months after VLCD LCD therapy. Disappearance of hyperandrogenism may be attributed to improved insulin resistance and hyperinsulinemia. VLCD LCD therapy may thus be effective in ameliorating gonadal dysfunction in obese patients with hyperandrogenism. Note that sex hormone abnormality could be complicated in severely obese patients, and that early treatment such as VLCD LCD therapy may be useful.

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