Blood Glucose Stabilization by Predinner Insulin Glargine in Intensive Therapy with Rapid-Acting Insulin Analog

DOI Web Site 1 Citations 12 References
  • Nakayama Hitomi
    Deapartment of Endocrinology and Metabolism, Kurume University School of Medicine
  • Kato Tomoko
    Deapartment of Endocrinology and Metabolism, Kurume University School of Medicine
  • Kaku Hiroo
    Deapartment of Endocrinology and Metabolism, Kurume University School of Medicine
  • Niizeki Fumi
    Deapartment of Endocrinology and Metabolism, Kurume University School of Medicine
  • Mukai Tokunori
    Deapartment of Endocrinology and Metabolism, Kurume University School of Medicine
  • Eguchi Hiroyuki
    Deapartment of Endocrinology and Metabolism, Kurume University School of Medicine
  • Tanaka Kayo
    Deapartment of Endocrinology and Metabolism, Kurume University School of Medicine
  • Hara Kento
    Deapartment of Endocrinology and Metabolism, Kurume University School of Medicine
  • Mitsuzaki Kenshi
    Deapartment of Endocrinology and Metabolism, Kurume University School of Medicine
  • Nakayama Satoshi
    Deapartment of Endocrinology and Metabolism, Kurume University School of Medicine
  • Hirota Naotoshi
    Deapartment of Endocrinology and Metabolism, Kurume University School of Medicine
  • Yamada Kentaro
    Deapartment of Endocrinology and Metabolism, Kurume University School of Medicine

Bibliographic Information

Other Title
  • 超速効型インスリンを用いた強化療法における夕食前グラルギン注射の血糖安定化作用
  • チョウソッコウガタ インスリン オ モチイタ キョウカ リョウホウ ニ オケル ユウショクゼン グラルギン チュウシャ ノ ケットウ アンテイカ サヨウ

Search this article

Abstract

To compare the effects of NPH insulin at bedtime and insulin glargine before dinner combined with premeal rapid-acting-insulin analog injections, we assessed daily plasma glucose profiles in 177 inpatients with Type 1 (n=61) or Type 2 (n=116) diabetes. We found no significant difference in doses of either rapid-acting-insulin analog or NPH/glargine, but Type 2 diabetes patients showed significantly lower post breakfast and post dinner glucose when injected with insulin glargine. Type 1 diabetes patients showed bedtime NPH associated with an elevated low blood glucose index at 03:00. Predinner glargine significantly reduced nocturnal hypoglycemic risk. These observations showed that predinner glargine combinated with rapid-acting-insulin analog acts more beneficially on postprandial hyperglycemia in Type 2 diabetes and nocturnal hypoglycemic risk in Type 1 diabetes than bedtime NPH in equivalent doses.

Journal

Citations (1)*help

See more

References(12)*help

See more

Keywords

Details 詳細情報について

Report a problem

Back to top