c-Fos immunoreactivity of neural cells in intoxication due to high-dose methamphetamine
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- Tomita Masafumi
- Department of Medical Toxicology, Kawasaki Medical School
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- Katsuyama Hironobu
- Department of Public Health, Kawasaki Medical School
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- Watanabe Yoko
- Department of Natural Sciences, Kawasaki Medical School
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- Shibaike Yoshinori
- Department of Medical Toxicology, Kawasaki Medical School
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- Yoshinari Haruhiko
- Department of Medical Toxicology, Kawasaki Medical School
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- Tee Jia Wei
- Department of Medical Toxicology, Kawasaki Medical School
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- Iwachidou Nobuhisa
- Tissue Biology & Electron Microscopy Research Center, Kawasaki Medical School
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- Miyamoto Osamu
- Department of Physiology 2, Kawasaki Medical School
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抄録
Methamphetamine (METH) is a powerful and toxic psychostimulant that is abused worldwide. Although many studies of its toxic functions have been done on animals and humans, the mechanism is still poorly understood. In addition, the doses of METH examined have often been low. Here, we investigated the effects of intoxication due to administration of 20 mg/kg METH on neuronal activity. The mice showed hyperthermia and stereotyped behavior during 60 min after injection. We examined plasma stress hormone levels, which indicated that exposure to METH stimulated the hypothalamic-pituitary-adrenal (HPA) axis and caused release of stress hormones soon after injection. The maximum levels of adrenocorticotropic hormone and corticosterone occurred 10 and 60 min, respectively, after injection. We examined c-Fos protein in 16 different brain regions at 60 min post injection to identify potential brain regions subject to the stimulant effect. Nine regions, including the anterior hypothalamic area, medial preoptic area, lateral hypothalamic area, paraventricular thalamic nucleus, lateral anterior hypothalamic nucleus, lateral septum, striatum, nucleus accumbens, and amygdala, showed a significant increase in c-Fos expression, while the other seven regions did not. These results indicate that responsive neurons in the regions containing c-Fos immunoreactivity (Fos-IR) may undergo cellular reaction to high-dose METH administration. The present study provides support for a relationship among hyperthermia, the HPA axis and neuronal activities in limited brain regions on exposure to 20 mg/kg METH.
収録刊行物
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- The Journal of Toxicological Sciences
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The Journal of Toxicological Sciences 38 (5), 671-678, 2013
一般社団法人 日本毒性学会
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詳細情報 詳細情報について
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- CRID
- 1390001204904391680
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- NII論文ID
- 10031191725
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- NII書誌ID
- AN00002808
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- COI
- 1:CAS:528:DC%2BC3sXhslyitb3I
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- ISSN
- 18803989
- 03881350
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- NDL書誌ID
- 024933888
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- PubMed
- 24025783
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可