Relationship between High-sensitivity C-reactive Protein and Atherosclerotic Risk Markers in Coronary Heart Disease and Diabetic Microangiopathy.

Saito Shigenobu, Kashiwazaki Koichi, Hirano Tsutomu, Koba Shinji, Katagiri Takashi, Adachi Mitsuru, Yoshino Gen

doi:10.11213/tonyobyo1958.45.391

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Other Title

冠状動脈性心疾患および糖尿病細小血管病変における高感度ＣＲＰと動脈硬化リスクマーカーの関係
カンジョウドウミャクセイシンシッカンオヨビトウニョウビョウサイショウケッカンビョウヘンニオケルコウカンド CRP トドウミャクコウカリスクマーカーノカンケイ

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Abstract

High sensitivity C-reactive protein (HS-CRP) was evaluated in patients with diabetesmellitus (DM) or coronary heart disease (CHD). Diabetic patients with retinopathy (DR) were further classified to determine the relevance of microangiopathy to HS-CRP. No significant difference was seen in HS-CRP between controls and DM or DR patients.In contrast, HS-CRP was significantly higher in all CHD patients, regardless of DM or DR. In all subjects, HS-CRP correlated significaly with HDL-cholesterol and BMI. Multivariate regression analysis showed a significant contribution of HOMA-R or BMI to HS-CRP. HOMA-R was selected as an explanatory factor in all subjects or all CHD patients, and BMI in controls or all diabetic patients. In all subjects, multiple logistic regression analysis showed that the presence of CHD and insulin resistance were significant independent variables.In CHD patients, HS-CRP increasedindependently of T-C (LDL-C), LDL particle size, BMI and HOMA-R.These results suggest that HS-CRP may be a marker for coronary heart disease rather than a marker for insulin resistance or obesity.

Journal

Journal of the Japan Diabetes Society

Journal of the Japan Diabetes Society 45 (6), 391-397, 2002

THE JAPAN DIABETES SOCIETY

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