Relationship between High-sensitivity C-reactive Protein and Atherosclerotic Risk Markers in Coronary Heart Disease and Diabetic Microangiopathy.
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- Saito Shigenobu
- First Department of Internal Medicine, Showa University School of Medicine
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- Kashiwazaki Koichi
- First Department of Internal Medicine, Showa University School of Medicine
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- Hirano Tsutomu
- First Department of Internal Medicine, Showa University School of Medicine
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- Koba Shinji
- Third Department of Internal Medicine, Showa University School of Medicine
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- Katagiri Takashi
- Third Department of Internal Medicine, Showa University School of Medicine
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- Adachi Mitsuru
- First Department of Internal Medicine, Showa University School of Medicine
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- Yoshino Gen
- Department of Laboratory Medicine, Toho University School of Medicine
Bibliographic Information
- Other Title
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- 冠状動脈性心疾患および糖尿病細小血管病変における高感度CRPと動脈硬化リスクマーカーの関係
- カンジョウ ドウミャクセイシン シッカン オヨビ トウニョウビョウサイショウ ケッカン ビョウヘン ニ オケル コウカンド CRP ト ドウミャク コウカ リスクマーカー ノ カンケイ
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Description
High sensitivity C-reactive protein (HS-CRP) was evaluated in patients with diabetesmellitus (DM) or coronary heart disease (CHD). Diabetic patients with retinopathy (DR) were further classified to determine the relevance of microangiopathy to HS-CRP. No significant difference was seen in HS-CRP between controls and DM or DR patients.In contrast, HS-CRP was significantly higher in all CHD patients, regardless of DM or DR. In all subjects, HS-CRP correlated significaly with HDL-cholesterol and BMI. Multivariate regression analysis showed a significant contribution of HOMA-R or BMI to HS-CRP. HOMA-R was selected as an explanatory factor in all subjects or all CHD patients, and BMI in controls or all diabetic patients. In all subjects, multiple logistic regression analysis showed that the presence of CHD and insulin resistance were significant independent variables.In CHD patients, HS-CRP increasedindependently of T-C (LDL-C), LDL particle size, BMI and HOMA-R.These results suggest that HS-CRP may be a marker for coronary heart disease rather than a marker for insulin resistance or obesity.
Journal
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- Journal of the Japan Diabetes Society
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Journal of the Japan Diabetes Society 45 (6), 391-397, 2002
THE JAPAN DIABETES SOCIETY
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Details 詳細情報について
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- CRID
- 1390001204904439936
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- NII Article ID
- 10009510021
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- NII Book ID
- AN00166576
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- ISSN
- 1881588X
- 0021437X
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- NDL BIB ID
- 025094345
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- Text Lang
- ja
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- Data Source
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- JaLC
- NDL
- CiNii Articles
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- Abstract License Flag
- Disallowed