Blood Lactate and Pyruvate Levels in Elderly Diabetic Patients Treated with Metformin.

DOI Web Site 1 Citations 21 References
  • Kuroda Shoji
    Dept. of Internal Medicine, Harima Hospital of Ishikawajima-Harima Heavy Industries, Health Insurance Society
  • Sakaguchi Kazuhiko
    Dept. of Internal Medicine, Harima Hospital of Ishikawajima-Harima Heavy Industries, Health Insurance Society
  • Onishi Yutaka
    Dept. of Internal Medicine, Harima Hospital of Ishikawajima-Harima Heavy Industries, Health Insurance Society
  • Teranishi Tetsuya
    Dept. of Internal Medicine, Harima Hospital of Ishikawajima-Harima Heavy Industries, Health Insurance Society
  • Ikehara Hisatomo
    Dept. of Internal Medicine, Harima Hospital of Ishikawajima-Harima Heavy Industries, Health Insurance Society
  • Sakamoto Norikazu
    Dept. of Internal Medicine, Harima Hospital of Ishikawajima-Harima Heavy Industries, Health Insurance Society
  • Fujisawa Takashi
    Dept. of Internal Medicine, Harima Hospital of Ishikawajima-Harima Heavy Industries, Health Insurance Society
  • Maeda Mitsuo
    Dept. of Internal Medicine, Harima Hospital of Ishikawajima-Harima Heavy Industries, Health Insurance Society

Bibliographic Information

Other Title
  • 高齢者糖尿病患者に対するメトホルミンの安全性に関する検討　　空腹時乳酸，ピルビン酸値に関して
  • コウレイシャ トウニョウビョウ カンジャ ニ タイスル メトホルミン ノ アンゼンセイ ニ カンスル ケントウ : クウフクジ ニュウサン,ピルビンサンチ ニ カンシテ
  • 空腹時乳酸, ピルビン酸値に関して

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Old age is one of many reported contraindications to metformin therapy. We measured plasma lactate and pyruvate in type 2 diabetes patients with or without metformin. Plasma lactate was not elevated in the metformin-treated group. Plasma lactate levels did not correlate with age. Patients with high lactate had alcoholism, heart failure, asthma, and arteriosclerosis obliterans. One was administered excess metformin. These cases were generally contraindicated, suggesting that age alone should not be considered a contraindication to metformin therapy.

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