書誌事項
- タイトル別名
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- Decreased Interleukin-6(IL-6) Synthesis in Sciatic Nerve Axotomy on Streptozotocin-Induced Diabetic Rats.
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It is well-known that impaired nerve fiber regeneration is one of the major pathogens in diabetic neuropathy. In other hand, it has also been suggested that IL-6, one of the inflammatory cytokines, has an essential role in eliciting the nerve fiber regeneration.<BR>We examined interleukin-6 (IL-6) levels and myelinated fiber regeneration in axotomized sciatic nerve in streptozotocin-induced diabetic rats. In non-axotomized nerve, using bioassay analysis, IL-6 was found to be expressed at low levels. However, a rapid but transient increase in IL-6 synthesis occurred in axotomized nerves, peak levels being reached less than three days after nerve injury. At 35 days after axotomy, myelinated fiber regeneration was quantitated using light microscopic morphometry. Regenerated fiber density was significantly reduced in a diabetic rat, to 32% of thatin a control, rat, and fiber size also decreased. Although both sections demonstrated some remnant of fiber degeneration, such as macrophage invasion and a destructive myelin, regeneration cluster was much more noticeable in the control rat.<BR>The study we present here demonstrates decreased IL-6 synthesis in experimental diabetic neuropathy in vivo, but the mechanism of IL-6 suppression is still unknown. Further evaluation of the dynamics of recruited macrophage and functional deficits of Schwann cells on the nerve injury are required.
収録刊行物
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- 糖尿病
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糖尿病 43 (8), 649-655, 2000
一般社団法人 日本糖尿病学会
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詳細情報 詳細情報について
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- CRID
- 1390001204904461440
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- NII論文ID
- 130004338690
- 10006817712
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- NII書誌ID
- AN00166576
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- ISSN
- 1881588X
- 0021437X
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可