Effect of Urapidil on Diabetic Neurogenic Bladder

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  • 糖尿病性神経因性ぼうこうに対するウラピジルの効果と評価法
  • トウニョウビョウセイ シンケイインセイ ボウコウ ニ タイスル ウラピジル ノ コウカ ト ヒョウカホウ

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Abstract

Urapidil was administered orally at 30mg/day for 1 month to 22 patients (17 men and 5 women) with diabetes and bladder dysfunction.After confirming the absence of adverse reactions, the dose was increased to 60mg/day for another 5 months.Urine flow was assessed with a uroflowmeter at the end of administration. Patients were assessed for symptoms using the International Prostate Symptom Score (IPSS) and the QOL score (an index of satisfaction).Uroflowmetry showed that maximum urine flow improved from 12.3±6.2 to 15.5±10.6 (ml/s), and that mean urine flow improved from 5.2±2.6 to 7.5±4.6 (ml/s), although neither change was statistically significant.IPSS and QOL scores decreased significantly, however, from 20.1±9.2 to 10.0±7.8 and 4.8±1.0 to 2.8±1.4.Efficacy, determined from Guidelines for Clinical Studies on Urinary Dysfunction, was 62.8%.Efficacy in patients with a pretreatment single voided urine volume of less than 200ml increased to 81.8%.Urapidil may thus be useful in treating diabetic neurogenic bladder, although it is important to select appropriate methods for evaluating response.

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