Toxicomics Report : Induction of the fatty acid 2-hydroxylase (FA2H) gene by Δ⁹-tetrahydrocannabinol in human breast cancer cells

DOI Web Site Web Site PubMed 被引用文献10件 参考文献17件
  • Takeda Shuso
    Department of Molecular Biology, Daiichi University of Pharmacy
  • Harada Mari
    Department of Molecular Biology, Daiichi University of Pharmacy
  • Su Shengzhong
    Center for Molecular Toxicology and Carcinogenesis, 101 Life Sciences Building, Pennsylvania State University
  • Okajima Shunsuke
    Department of Molecular Biology, Daiichi University of Pharmacy
  • Miyoshi Hiroko
    Department of Molecular Biology, Daiichi University of Pharmacy
  • Yoshida Kazutaka
    Department of Molecular Biology, Daiichi University of Pharmacy
  • Nishimura Hajime
    Department of Molecular Biology, Daiichi University of Pharmacy
  • Okamoto Yoshiko
    Department of Molecular Biology, Daiichi University of Pharmacy
  • Amamoto Toshiaki
    NEUES Corporation
  • Watanabe Kazuhito
    Department of Hygienic Chemistry, Faculty of Pharmaceutical Sciences, Hokuriku University
  • Omiecinski Curtis J
    Center for Molecular Toxicology and Carcinogenesis, 101 Life Sciences Building, Pennsylvania State University
  • Aramaki Hironori
    Department of Molecular Biology, Daiichi University of Pharmacy

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タイトル別名
  • Induction of the <i>fatty acid 2-hydroxylase (FA2H)</i> gene by Δ<sup>9</sup>-tetrahydrocannabinol in human breast cancer cells
  • Induction of the fatty acid 2-hydroxylase (FA2H) gene by Δ9-tetrahydrocannabinol in human breast cancer cells

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抄録

To investigate gene(s) being regulated by ∆9-tetrahydrocannabinol (∆9-THC), we performed DNA microarray analysis of human breast cancer MDA-MB-231 cells, which are poorly differentiated breast cancer cells, treated with ∆9-THC for 48 hr at an IC50 concentration of approximately 25 µM. Among the highly up-regulated genes (> 10-fold) observed, fatty acid 2-hydroxylase (FA2H) was significantly induced (17.8-fold). Although the physiological role of FA2H has not yet been fully understood, FA2H has been shown to modulate cell differentiation. The results of Oil Red O staining after ∆9-THC exposure showed the distribution of lipid droplets (a sign of the differentiated phenotype) in cells. Taken together, the results obtained here indicate that FA2H is a novel ∆9-THC-regulated gene, and that ∆9-THC induces differentiation signal(s) in poorly differentiated MDA-MB-231 cells.

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