Effectiveness of Step-up Bolus Insulin Addition on Combination Therapy with Sulfonylurea and Once-daily Insulin Glargine in Japanese Type 2 Diabetic Patients (JUN-LAN Study 7)

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  • Okayama Kaede
    Department of Medicine, Metabolism and Endocrinology, Juntendo University School of Medicine
  • Goto Hiromasa
    Department of Medicine, Metabolism and Endocrinology, Juntendo University School of Medicine
  • Yoshihara Tomoaki
    Department of Medicine, Metabolism and Endocrinology, Juntendo University School of Medicine
  • Ikeda Fuki
    Department of Medicine, Metabolism and Endocrinology, Juntendo University School of Medicine
  • Fukui Munenori
    Department of Pharmacy, Chiba Tokushukai Hospital
  • Azuma Satsuki
    Department of Pharmacy, Chiba Tokushukai Hospital
  • Fujitani Yoshio
    Department of Medicine, Metabolism and Endocrinology, Juntendo University School of Medicine Center for Therapeutic Innovations in Diabetes, Juntendo University Graduate School of Medicine
  • Watada Hirotaka
    Department of Medicine, Metabolism and Endocrinology, Juntendo University School of Medicine
  • Kawamori Ryuzo
    Department of Medicine, Metabolism and Endocrinology, Juntendo University School of Medicine Center for Therapeutic Innovations in Diabetes, Juntendo University Graduate School of Medicine Sportology Center, Juntendo University Graduate School of Medicine Center for Ilet Biology and Regeneration, Juntendo University Graduate School of Medicine
  • Hirose Takahisa
    Department of Medicine, Metabolism and Endocrinology, Juntendo University School of Medicine Center for Therapeutic Innovations in Diabetes, Juntendo University Graduate School of Medicine

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Other Title
  • 2型糖尿病のSU薬とグラルギン併用療法効果不十分例における超速効型インスリンの段階的追加法の検討(JUN-LAN Study 7)
  • 2ガタ トウニョウビョウ ノ SUヤク ト グラルギン ヘイヨウ リョウホウ コウカ フジュウブンレイ ニ オケル チョウソッコウガタ インスリン ノ ダンカイテキ ツイカホウ ノ ケントウ JUN LAN Study 7

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We have evaluated the effectiveness of step-up bolus insulin addition in 16 type 2 diabetic patients with a mean HbA1c of 8.12±0.92% who underwent combination therapy with sulfonylurea and once-daily insulin glargine (bedtime or morning) but whose HbA1c was ≥7.0% over 1 year.<br>Patients underwent randomly added bolus insulin before breakfast (n=8) or dinner (n=8). After 12 weeks of treatment, 6 whose HbA1c was ≥7.0% and who agreed to step-up addition of rapid-acting insulin underwent this therapy. After 24 weeks treatment, mean HbA1c in all patients improved from 8.12±0.92% to 7.19±0.54%. Body weight increased slightly but significantly during the study.<br>These results suggest that step-up bolus insulin addition during combination therapy with sulfonylurea and once-daily glargine is effective in lowering HbA1c and easily tolerated in patients having difficulty in undergoing intensive insulin therapy.

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