書誌事項
- タイトル別名
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- A Case of Insulin Allergy with Reaction to Short-Acting and Intermediate-Acting Insulins but not to Long-Acting Insulins.
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説明
A 46-year-old man with NIDDM and pulmonary tuberculosis was admitted to our hospital because of generalized fatigue and cough. As glycemic control was poor, treatment with mixture injections of short-acting and intermediate-acting insulins twice a day was begun. After treatment with these preparations for two months, he noticed local, itchy, wheal-and-flare reactions at the sites of injection, indicative of an insulin allergy.<BR>Human insulin-specific bound IgE was positive and insulin antibody formation was elevated to 89.8%(≤10%). Intradermal testing for insulin allergy was performed with founteen commercially available preparations of human, porcine and bovine insulins. All short-acting and intermediate-acting insulins produced allergic reactions, whereas none of the long-acting insulins was allergenic. These long-acting insulins were monoclinic insulin crystals. when decrystallized by lowering the pH from 7.0 to 3.0, even these insulins induced a positive reaction. The findings indicate that, in this case, the monoclinic crystallized structure of human insulin may have masked the antigenicity by which the short-and intermediate-acting insulins induced allergic reactions.
収録刊行物
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- 糖尿病
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糖尿病 39 (3), 205-210, 1996
一般社団法人 日本糖尿病学会
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詳細情報 詳細情報について
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- CRID
- 1390001204905362304
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- NII論文ID
- 130004338273
- 10005564553
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- NII書誌ID
- AN00166576
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- ISSN
- 1881588X
- 0021437X
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可