トリフェニルすずフルオライド１回経口投与ウサギにみられる一過性糖尿病性高脂血症及び可逆性耐糖能低下

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タイトル別名
  • Transient Diabetic Lipemia and Reversible Glucose Intolerance in Rabbits after a Single Dose of Triphenyltin Fluoride
  • トリフェニル スズ フルオライド 1カイ ケイコウ トウヨ カト ニ ミラレル

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抄録

Phenyltin compounds have been widely used as agricultural chemicals and marine antifoulants. They have been intensively studied from the stand-point of toxicity. However, the in vivo mechanisms of their toxicity and metabolism remain poorly understood. We previously reported that oral administration of 100 mg/kg body weight of tripheyltin fluoride (TPTF) to rabbits evoked hypertriglyceridemia. The present experiments were conducted to elucidate the mechanism of such TPTFinduced hypertriglyceridemia by following the time course of fasting blood glucose (FBS), glucose tolerance tests, serum IRI, serum lipids and lipoprotein lipase (LPL) activity, and also by determining the influence of insulin on the TPTF-induced hypertriglyceridemia. The pancreatic islets, liver and kidney of the rabbits were also examined histologically. After TPTF administration, the FBS and plasma triglyceride concentration were elevated significantly (p<0.02) for about 10 days. On the other hand, the PHLA (plasma postheparin lipolytic activity) and LPL in adipose tissue were remarkably decreased (p<0.02), while chyromicron and VLDL were increased.<BR>Insulin treatment for 1 or 2 days increased the LPL activity to the normal level in these rabbits, but withdrawal of insulin from the insulin-treated rabbits again resulted in a decrease in LPL activity. These results indicate that a single oral dose of TPTF evoked diabetic lipemia and glucose intolerance due to insulin deficiency. The IRI level was decreased before and even after glucose infusion during these periods. Microscopic examinations revealed no remarkable changes in the pancreas islets, liver and kidney. Pancreatic B-cells contained normal amounts of granules at the maximal hyperlipemic stage. These findings suggest that TPTF interferes with insulin release from rabbit beta-cells, and/or TPTF decreases the sensitivity of islets tQrelease insulin in response to increasing levels of blood glucose.

収録刊行物

  • 糖尿病

    糖尿病 24 (6), 669-677, 1981

    一般社団法人 日本糖尿病学会

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