Insulin Resistance in Cushing's Syndrome and in Preclinical Cushing's Syndrome Evaluated by Euglycemic Hyperinsulinemic Glucose Clamping Befor and After Adrenalectomy in 2 Cases.
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- Hamasaki Akihiro
- Department of Internal Medicine, Otsu Red Cross Hospital
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- Taniguchi Takao
- Department of Internal Medicine, Otsu Red Cross Hospital
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- Ueno Hiroyuki
- Department of Internal Medicine, Otsu Red Cross Hospital
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- Matsuda Isao
- Department of Internal Medicine, Otsu Red Cross Hospital
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- Tamegai Michiko
- Department of Internal Medicine, Otsu Red Cross Hospital
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- Seko Shuji
- Department of Internal Medicine, Otsu Red Cross Hospital
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- Kuno Shinichiro
- Department of Internal Medicine, Otsu Red Cross Hospital
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- Yamada Yuichiro
- Department of Metabolism & Clinical Nutrition, Graduate School of Medicine, Kyoto University
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- Seino Yutaka
- Department of Metabolism & Clinical Nutrition, Graduate School of Medicine, Kyoto University
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- Okamoto Motozumi
- Department of Internal Medicine, Otsu Red Cross Hospital
Bibliographic Information
- Other Title
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- Glucose clamp法により副腎摘除術治療前後にインスリン抵抗性を評価し得たCushing症候群およびpreclinical Cushing症候群の2症例
- ショウレイ ホウコク Glucose clampホウ ニ ヨリ フクジンテキジョジュツ チリョウ ゼンゴ ニ インスリン テイコウセイ オ ヒョウカ シエタ Cushing ショウコウグン オヨビ preclinical Cushing ショウコウグン ノ 2 ショウレイ
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Abstract
We report 2 patients with hypercortisolism, 1 induced by Cushing's syndrome and the other by preclinical Cushing's syndrome.<BR>Case 1: A 65-year-old woman admitted for evaluation of a left adrenal tumor discovered by computed tomography (CT) for the further study of hypertension showed no clinical evidence of Cushing's syndrome.<BR>Case 2: A 66-year-old woman admitted for leg fatigue and edematous face had moon face, central obesity, and ecchymosis.<BR>In both patients, the diurnal rhythm of plasma cortisol was absent, an overnight 8 mg dexamethasone test showed no suppression of the plasma cortisol level, and plasma ACTH was supressed. From these findings and imaging examinations, we diagnosed the patients as preclinical Cushing's syndrome (Case 1) and Cushing's syndrome (Case 2) due to left adrenal adenoma. In both patients, 75g OGIT administered before and after surgical treatment showed improved glucose tolerance from DM to IGT. In the insulin resistance evaluation with euglycemic hyperinsulinemic glucose clamping, the metabolic clearance rate (MCR) for glucose improved from 4.2 to 10.1ml/kg/min (Case 1) and from 3.8 to 5.4ml/kg/min (Case2).
Journal
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- Journal of the Japan Diabetes Society
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Journal of the Japan Diabetes Society 45 (4), 237-244, 2002
THE JAPAN DIABETES SOCIETY
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Details 詳細情報について
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- CRID
- 1390001204905631488
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- NII Article ID
- 130004115360
- 10008700701
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- NII Book ID
- AN00166576
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- ISSN
- 1881588X
- 0021437X
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- NDL BIB ID
- 025095168
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- Text Lang
- ja
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- Data Source
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- JaLC
- NDL
- CiNii Articles
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- Abstract License Flag
- Disallowed