Indices of Urinary and Serum C-peptide Corrected with Fasting Plasma Glucose for Decision-making of Insulin Therapy in Type 2 Diabetes-Validation and Comparison

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  • Asano Takako
    Department of Endocrinology and Metabolism, Tokyo Teishin Hospital Division of Endocrinology and Metabolism, Tokyo Medical and Dental University Graduate School
  • Kawamura Mitsunobu
    Department of Endocrinology and Metabolism, Tokyo Teishin Hospital
  • Watanabe Takayuki
    Department of Endocrinology and Metabolism, Yokohama Minato Sekijuji Hospital
  • Abe Makiko
    Department of Endocrinology and Metabolism, Tokyo Teishin Hospital
  • Chin Rina
    Department of Endocrinology and Metabolism, Tokyo Teishin Hospital
  • Miyazaki Shigeru
    Department of Endocrinology and Metabolism, Tokyo Teishin Hospital
  • Hirata Yukio
    Division of Endocrinology and Metabolism, Tokyo Medical and Dental University Graduate School

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Other Title
  • 2型糖尿病におけるインスリン治療の要否判定の指標としての尿中Cペプチド補正値(UCC)およびCペプチドインデックス(CPI)の有用性
  • 2ガタ トウニョウビョウ ニ オケル インスリン チリョウ ノ ヨウヒ ハンテイ ノ シヒョウ ト シテノ ニョウチュウ C ペプチド ホセイチ UCC オヨビ C ペプチド インデックス CPI ノ ユウヨウセイ

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Two indices termed urinary C-peptide corrected value (UCC) and CPR index (CPI) mean [24 hour-urinary C-peptide (U-CPR)/fasting plasma glucose (FPG)] and [serum C-peptide (S-CPR)/FPG×100]. We examined validation for a clinical decision of whether insulin treatment is required for type 2 diabetes and compared these indices. Subjects were 180 type 2 diabetic patients with HbA1c less than 8% if treated with either oral medication or diet therapy, and without severe complications. They were divided into three groups by therapy at the end of observation: insulin treatment (I), oral medication (O), and diet therapy (D). Both CPI and UCC of group I were significantly (p<0.001) lower than those of group O and D on admission. From ROC curves, both CPI and UCC were more useful than U-CPR and S-CPR, and CPI and UCC were almost comparable. In conclusion, both CPI and UCC prove to be equally useful indices for a clinical decision or whether insulin was required for treatment of type 2 diabetic patients 2 years in the future.

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