書誌事項
- タイトル別名
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- An NIDDM Patient with Repeated Postprandial Hypotension Successfully Treated with Amezinium Methylsulfate.
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説明
We encountered an NIDDM patients with the complication of postprandial hypotension (PPH) who repeatedly experienced syncope after meals. The patient was successfully treated with amezenium methylsulfate which increased endogenous norepinephrine levels and blood pressure.<BR>The patient, a 66-year-old woman, was diagnosed with NIDDM in 1971 and treated with oral hypoglycemic agents. Thereafter, she maintained poor glycemic control. Since she repeatedly experienced post prandial syncope with palpitation which lasted up to ten minutes and occurred once or twice amonth beginning in February 1993, she was hospitalized in August 1993. We noted that she had a history of syncope after meals, and performed 24-hour ambulatory blood pressure monitoring (AMBP) and 2-hour AMBP during a 75g oral glucose tolerance test (OGTT). She was diagnosed with NIDDM complicated by PPH based on complaints of general fatigue as well as a systemic blood pressure (SBP) decrease of 25mmHg. The concentrations of plasma norepinephrine (NE) were 338pg/ml before OGTT and 268pg/ml after OGTT. When she was given 10mg of amezinium methylsulfate (AM) per os 2hours before OGTT, the decrease in SBP was only 12 mmHg. The patient had no further complaints and plasma NE concentrations increased from 290 pg/ml before OGTT to 348pg/ml after OGTT.<BR>These results indicate that PPH in this case was caused by the intake of meals including glucose. PPH improved rapidly with AM administration which increased plasma NE.
収録刊行物
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- 糖尿病
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糖尿病 39 (2), 153-159, 1996
一般社団法人 日本糖尿病学会
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詳細情報 詳細情報について
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- CRID
- 1390001204905735168
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- NII論文ID
- 130004338263
- 10005564435
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- NII書誌ID
- AN00166576
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- ISSN
- 1881588X
- 0021437X
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可
