Five Year's Time-Course Studies on the Changes of Glucose Tolerance

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  • Katsumata Kazuo
    Third Department of Internal Medicine, Nagoya University School of Medicine
  • Tuchida Isamu
    Third Department of Internal Medicine, Nagoya University School of Medicine

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Other Title
  • 糖尿病発病過程における耐糖能の推移
  • トウニョウビョウ ハツビョウ カテイ ニ オケル タイトウノウ ノ スイイ トクニ GTT , CGTT ト ノ カンケイ ニ ツイテ
  • Cortison-Glucose Tolerance Test in Potential and Latent Diabetic Patients
  • とくにGTT, CGTTとの関係について

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Abstract

100 g glucose tolerance test (GTT) and cortisonglucose tolerance test (CGTT) were performed on 43 spersons of 2 potential, 3 renale diabetic and 38 latent diabetic patients. GTT and CGTT of 43 persons were ystematically tested during 5 years. Eighteen persons had diabetic relatives, 25 persons had not. The grades of abnormalities of GTT and CGTT were classified to N, L and D, depending on their blood glucose values at 1 and 2 hours after glucose loading.<BR>The persons who showed L in GTT and L or D in CGTT at the beginning of these experiments became diabetic in 4-5 years more frequently than the persons who showed N in GTT or CGTT at the beginning of experiment. Especially in the cases of L, D type of CGTT, this tendency was apparent regardless to their data in GTT. Considering the changes of GTT in each person during the 5 year's observation, data of GTT was well coincide with that of CGTT.<BR>Judging from the results of time-course studies on the latent diabetic persons who showed N or L in GTT, they were supposed to have constant metabolic disorders and the considerable possibility to become diabetic if they showed D in CGTT.<BR>It is recognized that CGTT is very valuable, especially to the cases with N or L in GTT, that is normal or slightly abnormal glucose tolerance.

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