Risk of Arteriosclerosis Increases with Renal Function Decline in Cases of Type 2 Diabetes with A Low Ankle-brachial Index

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  • 足関節上腕血圧比が低値を示す２型糖尿病患者では動脈硬化リスクが上昇するとともに腎機能が低下している
  • ソクカンセツ ジョウ ワン ケツアツヒ ガ テイチ オ シメス 2ガタ トウニョウビョウ カンジャ デワ ドウミャク コウカ リスク ガ ジョウショウ スル ト トモニ ジンキノウ ガ テイカ シテ イル

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Abstract

We studied the association of ankle-brachial index (ABI) values with arteriosclerosis and renal function in diabetes. The subjects were 510 type 2 diabetic outpatients (mean age, 65 years). Based on the ABI measurements, subjects were categorized as follows: ABI≤0.90, 0.91-1.00, 1.01-1.10, 1.11-1.20, and ≥1.21. The respective percentage of the five ABI categories were 8%, 10%, 32%, 38%, and 13%. Compared with the groups with a normal ABI (1.01-1.10, 1.11-1.20, ≥1.21), the group with a low ABI (≤0.90) had a significantly higher prevalence of cardiovascular disease and hypertension, were older, had a longer history of diabetes and higher pulse pressure, were at a more advanced nephropathy stage, and had a lower estimated glomerular filtration rate (eGFR). A significantly higher prevalence of cardiovascular disease and lower eGFR were seen after adjustment for confounding factors, such as arteriosclerosis-associated parameters and the nephropathy stage. The group with a low-normal ABI (0.91-1.00) also had a significantly higher prevalence of cardiovascular disease and lower eGFR, but the significance disappeared after adjustment for arteriosclerosis-associated parameters. Our study indicated that arteriosclerosis risk increased and renal function decreased in type 2 diabetes with a low ABI (≤0.90).<br>

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