Toxicomics Report : DNA microarray expression analysis of mouse kidney following cadmium exposure for 12 months

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  • Tokumoto Maki
    Laboratory of Chemical Toxicology and Environmental Health, Showa Pharmaceutical University Laboratory of Pharmaceutical Health Sciences, School of Pharmacy, Aichi Gakuin University
  • Lee Jin-Yong
    Laboratory of Pharmaceutical Health Sciences, School of Pharmacy, Aichi Gakuin University
  • Fujiwara Yasuyuki
    Laboratory of Pharmaceutical Health Sciences, School of Pharmacy, Aichi Gakuin University
  • Satoh Masahiko
    Laboratory of Pharmaceutical Health Sciences, School of Pharmacy, Aichi Gakuin University

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  • DNA microarray expression analysis of mouse kidney following cadmium exposure for 12 months

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Cadmium (Cd) is a toxic heavy metal and chronic exposure causes kidney injury. This study used DNA microarray analysis to examine gene expression in the kidney of mice chronically exposed to Cd. Female C57BL/6J mice were fed a 300 ppm Cd-containing diet or a control diet for 12 months. In comparison with control mice, the expression levels of 32 genes, including Hmox1 and Mt2, were elevated more than 2.0-fold, whereas 113 genes, including transport- and ubiquitination-related genes, were reduced less than 0.5-fold.

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