Oxygen Uptake Kinetics during Low Level Exercise in Type 2 Diabetic Patients.

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  • ２型糖尿病患者における定常運動負荷試験時の酸素摂取応答の検討
  • 2ガタ トウニョウビョウ カンジャ ニ オケル テイジョウ ウンドウ フカ シケンジ ノ サンソ セッシュ オウトウ ノ ケントウ

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Abstract

We measured the time constant (τ) of oxygen consumption (VO2) and oxygen deficit during low-level constant work rate exercise using a bicycle ergometer in 28 patients with type 2 diabetes mellitus and compared their data to that for 25 age-and gender-matched controls and 21 patients with chronic heart failure (CHF). We also measured peak VO2 and anaerobic threshold (AT) during graded exercise. Despite the lack of a significant difference in peak VO2 and AT among the 3 groups, diabetic patients had a longer τ(38±13s) than controls (27±8s, p<0.005). The τ in diabetic patients was even somewhat longer, though not significantly so, than that in CHF (36±10s). Diabetic patients also had a 1.5-fold increase in oxygen deficit compared to controls (306±120vs. 227±103ml/kg, P<0.05), which was somewhat greater, though not significantly so, than that in CHF (281±93ml/kg). These results suggest notable abnormalities in the cardiopulmonary response at the onset of low-level exercise in patients with type 2 diabetes who have no cardiovascular complications. This data may reflect impairment in both oxygen delivery to skeletal muscles and in oxygen utilization by skeletal muscles, indicating that exercise training programs should begin with low-level exercise in untrained adults with type 2 diabetes mellitus even in the absence of cardiovascular complications.

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