Cholesterol Contents of the Aorta, Renal Artery and Coronary Artery in Diabetics

Sato Tokutaro, Hoshi Haruhisa, Saito Kazuko, Inoue Michiko, Ito Masaaki, Kokubun Masaru, Saito Tsuyoshi, Yoshinaga Kaoru

doi:10.11213/tonyobyo1958.25.769

The cholesterol contents of the thoracic aorta, the renal artery and the coronary artery were determined in 6 nondiabetic and 21 diabetic autopsy subjects. The average ages of the nondiabetic and diabetic groups were 59.0 and 64.5 years, respectively. The mean duration of diabetes was 12.9 years.<BR>The dry weight of the aorta per area and of the arteries per length was greater in the diabetics than in the nondiabetics, suggesting that atherosclerosis was more advanced in the diabetics. The increase in cholesterol concentration in the arota with dry weight of the aorta per area, and in the renal artery with dry weight of the artery per length could be represented by the regression equations: y=-2.81+0.16x (r=0.718, p<0.001), and y=0.63+0.69x (r=0.478, p<0.05), respectively. The contents of cholesterol in the aorta, renal artery and coronary artery of the nondiabetics were 2.0±0.5%, 0.9±0.1% and 5.4 ± 3.1%, respectively, and a statistically significant difference was noted among them. The contents of cholesterol in these arteries in the diabetics were 4.9 ± 2.6, 2.7 ± 2.7%, and 5.4±3.7%, respectively. The content of cholesterol in the diabetics was greater in the groups with hypertension, ECG-abnormalities and long duration of diabetes, and that in the renal artery of the diabetics was markedly greater in the groups with proteinuria, long duration of diabetes and ECG-abnormalities.

Cholesterol Contents of the Aorta, Renal Artery and Coronary Artery in Diabetics

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