Species differences in toxicokinetic parameters of glycidol after a single dose of glycidol or glycidol linoleate in rats and monkeys
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- Wakabayashi Ken-ichi
- Safety Science Research Laboratories, Kao Corporation
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- Kurata Yoshimasa
- Nonclinical Research Center, Drug Development Service Segment, Mitsubishi Chemical Medience Corporation
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- Harada Tomoo
- Nonclinical Research Center, Drug Development Service Segment, Mitsubishi Chemical Medience Corporation
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- Tamaki Yasushi
- Safety Science Research Laboratories, Kao Corporation
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- Nishiyama Naohiro
- Safety Science Research Laboratories, Kao Corporation
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- Kasamatsu Toshio
- Safety Science Research Laboratories, Kao Corporation
この論文をさがす
説明
Glycidol fatty acid esters (GEs) have been identified as contaminants in refined edible oils. Although the possible release of glycidol (G) from GEs is a concern, little is known about the conversion of GEs to G in the human body. This study addressed the toxicokinetics of glycidol linoleate (GL) and G in male Crl:CD(SD) rats and cynomolgus monkeys. Equimolar amounts of GL (341 mg/kg) or G (75 mg/kg) were administered by gavage to each animal. G was found in both species after the G and GL administration, while plasma GL concentrations were below the lower limit of quantification (5 ng/ml) in both species. In rats, the administration of GL or G produced similar concentration-time profiles for G. In monkeys, the Cmax and AUC values after GL administration were significantly lower than those after G administration. The oral bioavailability of G in monkeys (34.3%) was remarkably lower than that in rats (68.8%) at 75 mg/kg G administration. In addition, plasma G concentrations after oral administration at three lower doses of GL or G were measured in both species. In monkeys, G was detected only at the highest dose of G. In contrast, the rats exhibited similar plasma G concentration-time profiles after GL or G administration with significantly higher G levels than those in monkeys. In conclusion, these results indicate that there are remarkable species differences in the toxicokinetics of GEs and G between rodents and primates, findings that should be considered when assessing the human risk of GEs.
収録刊行物
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- The Journal of Toxicological Sciences
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The Journal of Toxicological Sciences 37 (4), 691-698, 2012
一般社団法人 日本毒性学会
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詳細情報 詳細情報について
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- CRID
- 1390001204906628224
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- NII論文ID
- 10030502123
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- NII書誌ID
- AN00002808
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- COI
- 1:STN:280:DC%2BC38flsFaksw%3D%3D
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- ISSN
- 18803989
- 03881350
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- NDL書誌ID
- 023926054
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- PubMed
- 22863850
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可