Improved Glycemic Control with Naproxen for Inflammation in a Patient with Diabetes Caused by Interleukin-6-producing Pheochromocytoma

DOI Web Site
  • Furukawa Shoko
    Department of Diabetes and Endocrinology, University of Tsukuba Mito Medical Center
  • Fujihara Kazuya
    Department of Diabetes and Endocrinology, University of Tsukuba Mito Medical Center
  • Omoto Miyoko
    Department of Diabetes and Endocrinology, University of Tsukuba Mito Medical Center
  • Murayama Yuki
    Department of Diabetes and Endocrinology, University of Tsukuba Mito Medical Center
  • Wu Longmei
    Department of General Medicine, University of Tsukuba Mito Medical Center
  • Sasaki Susumu
    Department of General Medicine, University of Tsukuba Mito Medical Center
  • Kumagai Ryo
    Department of Diabetes and Endocrinology, University of Tsukuba Mito Medical Center
  • Isono Momoko
    Department of Diabetes and Endocrinology, University of Tsukuba Mito Medical Center Department of General Medicine, University of Tsukuba Mito Medical Center
  • Akine Dai
    Department of General Medicine, University of Tsukuba Mito Medical Center
  • Kobayashi Hiroyuki
    Department of General Medicine, University of Tsukuba Mito Medical Center
  • Takayashiki Norio
    Department of Pathology, University of Tsukuba Mito Medical Center
  • Suzuki Hiroaki
    Department of Diabetes and Endocrinology, University of Tsukuba Hospital
  • Shimano Hitoshi
    Department of Diabetes and Endocrinology, University of Tsukuba Hospital
  • Yagyu Hiroaki
    Department of Diabetes and Endocrinology, University of Tsukuba Mito Medical Center

Bibliographic Information

Other Title
  • IL-6産生褐色細胞腫において術前の炎症コントロールにより二次性糖尿病を改善し得た1例
  • 症例報告 IL-6産生褐色細胞腫において術前の炎症コントロールにより二次性糖尿病を改善し得た1例
  • ショウレイ ホウコク IL-6 サンセイ カッショク サイボウ シュ ニ オイテ ジュツゼン ノ エンショウ コントロール ニ ヨリ ニジセイ トウニョウビョウ オ カイゼン シエタ 1レイ

Search this article

Abstract

A 21-year-old woman was admitted to our hospital with a history of fever, fatigue, headache, palpitations and nausea lasting for one month. On a physical examination, her vital signs were as follows: T=38.5 °C, P=106/minute and BP=186/133 mmHg. Laboratory data revealed diabetes, with a random glucose level of 256 mg/dl and HbA1c level of 8.2 %, as well as both elevated C-reactive protein (40.21 mg/dl) and interleukin-6 (100 pg/ml) levels. In addition, computed tomography of the abdomen indicated a left adrenal tumor, while 123I-MIBG scintigraphy demonstrated accumulation of the isotope in the same region. Based on the patient's clinical data and elevated catecholamine levels, a diagnosis of pheochromocytoma was made. Consequently, almost immediate resolution of the fever followed by gradual normalization of the levels of clinical inflammatory markers was achieved after seven weeks of treatment with naproxen, doxazosin and propranolol. Furthermore, the C-reactive protein and interleukin-6 levels decreased to 0.15 mg/dl and 1.7 pg/ml, respectively, after increasing the dose of naproxen up to 600 mg, and the patient's glucose tolerance improved, enabling her to successfully stop insulin treatment prior to surgery. Therapy with naproxen for interleukin-6-producing pheochromocytoma is effective for improving secondary diabetes mellitus and may subsequently lead to reductions in the rates of perioperative complications associated with glucose intolerance.

Journal

Keywords

Details 詳細情報について

Report a problem

Back to top