Investigation of Depression in Diabetic Patients and the Usefulness of Paroxetine

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  • 糖尿病に伴ううつ病・うつ状態の検討とパロキセチンの有用性
  • 診断・治療(食事・運動・薬物治療) 糖尿病に伴ううつ病・うつ状態の検討とパロキセチンの有用性
  • シンダン ・ チリョウ(ショクジ ・ ウンドウ ・ ヤクブツ チリョウ) トウニョウビョウ ニ トモナウ ウツビョウ ・ ウツ ジョウタイ ノ ケントウ ト パロキセチン ノ ユウヨウセイ

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Abstract

The incidence of depression among diabetes mellitus patients was investigated, along with the effects of intervention using the antidepressant paroxetine. Depression was assessed by the 2-question method and Zung's Self-rating Depression Scale (hereafter: SDS). Among the 107 diabetes mellitus patients examined, 14 patients (13.1 %) were positive for depression in the 2-question screening, and the average SDS score was 38.4 points. The results showed significantly higher SDS scores among patients exhibiting insomnia, changes in appetite and body weight, as well as among males with nephropathy and patients with a known history of coronary artery disease. Patients who were suffering from depression or were in a depressive state were treated with paroxetine for 12 weeks. A significant decrease in the SDS score from the baseline level of 51.0±2 points to 42.0±5 points was observed after 12 weeks of treatment, and significant decreases in the HbA1c (JDS) level was also observed, compared to the pre-treatment levels. These results suggest that the early discovery of depression accompanying diabetes mellitus, together with appropriate intervention, may be beneficial from the standpoint of glycemic control, as well improving the patient's quality of life.<br>

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