TWO ANTI-CD (G) CASES PRODUCED BY Rh INCOMPATIBILITY BETWEEN MOTHER AND FETUS

DOI
  • Nishizawa Ryuji
    Department of Legal Medicine, School of Medicine, Gunma University
  • Nakajima Tamiko
    Department of Legal Medicine, School of Medicine, Gunma University
  • Furukawa Ken
    Department of Legal Medicine, School of Medicine, Gunma University

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Other Title
  • Ｒｈ式血液型不適合妊娠によって産生された抗ＣＤ（Ｇ）抗体の２症例

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In the Rh system of both cases fathers were CDe/cDE(R1R2), mothers cdE/cdE(r″r″) and infants CDe/cDE(R1R2). Mother's sera reacted with red cells containing C and (or) D antigen (s) including her husband. Absorption experiments in first case resulted that the agglutinin in mother's serum was completely absorbed with C-D+red cells while the absorption with C+D-cells remained anti-D specific antibody. Eluates from the sensitized red cells both types of C-D+and C+D-agglutinated C and D positive red cells. The results concluded that antibodies in first case were anti-D+CD (G). In second case anti-D and anti-C specific antibodies were remained in mother's serum after the absorption with C+D-and C-D+red cells respectively. Agglutination was observed in the reactions between eluates from red cells using absorption experiment, and C and D positive cells. Then antibodies in case 2 determined anti-C+D+CD (G). The anti-CD (G) antibodies were confirmed to belong to IgG class of immunoglobulin by 2-mercaptoethanol and ion-exchange chromatography analysis. No positive red cells reacted with case 2 mother's serum was found in 137 red cell samples of cde/cde(rr), cde/cdE(rr″) and cdE/cdE(r″r″). Both case infants received exchange blood transfusion and phototherapy after delivery.

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