A JAPANESE EXAMPLE OF THE LEWIS-NEGATIVE BOMBAY PHENOTYPE

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  • Ｌｅ（ａ―ｂ―）Ｂｏｍｂａｙ型の１例

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We recently found the first Japanese example of the Le(a-b-) Bombay phenotype. The propositus (Mr. Oka.) was a healthy 20-year-old male donor.<br>The red cells of Mr. Oka. failed to react with anti-A, anti-B, anti-A+B, anti-H (Ulex europaeus, Laburnum alpinum and Eel serum), the serum from an Ohm (Row II) and with the sera from six other Oh donors. His Lewis phenotype was Le(a-b-).<br>Propositus' serum contained anti-A, anti-B and anti-H. His saliva did not inhibit anti-A, anti-B, anti-H, anti-Lea and anti-Leb.<br>Testing 823, 498 donors with anti-H (Ulex europaeus), we found 2 Bombay and 3 para-Bombay phenotypes (0.00024%, 0.00036 respectively). Thus the gene frequency of the h-gene was roughly estimated to be 0.0015.

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