Ｄｏｎｏｒ　ｐｌａｓｍａｐｈｅｒｅｓｉｓ用膜型血しょう分離器の生体適合性の評価

DOI

書誌事項

タイトル別名
  • Evaluation of biocompatibility of three different membrane plasma separator for donor plasmapheresis.

抄録

Three membrane plasma separator, each of which was composed of module made from polyethylene (PE), polycarbonate (PC) or polypropylene (PP) membrane, were studied from a biocompatibility point of view, especially activation of complement (C3a, C5a), platelet (β-TG, PF-4), coagulation and fibrinolysis (FPA, Bβ-15-42) as well as hemolysis (free Hb, Hp, LDH).<br>Plasmapheresis for collection of 400ml plasma by these systems was carried out on 102 healthy donors.<br>Mean values of C3a and C5a in the donors blood were almost within normal range.<br>There was slightly activation of platelet, coagulation systems in return cycle (outlet) of these equipments.<br>Free Hb level in plasma was increased, which remained within normal range. Any adverse reach reaction caused directly by these equipments was not observed in all donors.<br>The collected plasma contained few platelets, no amount of C3a and C5a. In conclusion, these donor plasmapheresis systems can be safely performed and have a promising future for collection of a large amount of source plasma.

収録刊行物

  • 日本輸血学会雑誌

    日本輸血学会雑誌 36 (1), 10-19, 1990

    一般社団法人 日本輸血・細胞治療学会

詳細情報 詳細情報について

  • CRID
    1390001204909310080
  • NII論文ID
    130003706750
  • DOI
    10.3925/jjtc1958.36.10
  • ISSN
    18838383
    05461448
  • 本文言語コード
    ja
  • データソース種別
    • JaLC
    • Crossref
    • CiNii Articles
  • 抄録ライセンスフラグ
    使用不可

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