Degradation of Apoproteins in High Density Lipoproteins with High or Low Contents of Amyloid A Proteins by Polymorphonuclear Leukocytes in Vitro

DOI
  • Saheki Shuichi
    Department of Clinical Investigation and Central Clinical Laboratory, Ehime University
  • Takeda Akira
    Department of Clinical Investigation and Central Clinical Laboratory, Ehime University
  • Miyamoto Kazuo
    Department of Clinical Investigation and Central Clinical Laboratory, Ehime University
  • Takahashi Isao
    Department of Clinical Investigation and Central Clinical Laboratory, Ehime University
  • Murase Mitsuharu
    Department of Clinical Investigation and Central Clinical Laboratory, Ehime University
  • Takeuchi Nozomu
    Department of Clinical Investigation and Central Clinical Laboratory, Ehime University

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説明

Non-activated polymorphonuclear leukocytes did not degrade apo A proteins in high density lipoproteins in vitro, although it affected amyloid A proteins significantly. In contrast, leukocytes activated by phorbol myristate acetate metabolized all kinds of apoproteins in the lipoprotein, whether they had amyloid A proteins or not. The metabolic rates of amyloid A proteins and apo C-III were very rapid compared with those of apo A proteins.In contrast, lipid moieties of high density lipoproteins were hardly affected, with the exception of triglycerides, from incubation with either non-activated leukocytes and then lipoprotein particles were considered to become lipid-rich.<BR>These results suggest the possibility that high density lipoproteins could be metabolized in acute phases by activated leukocytes in circulating blood as well as through usual metabolic pathways.

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詳細情報 詳細情報について

  • CRID
    1390001204909908352
  • NII論文ID
    130004627071
  • DOI
    10.14921/jscc1971b.19.1_37
  • COI
    1:CAS:528:DyaK3cXksFKrsb8%3D
  • ISSN
    21874077
    03705633
  • 本文言語コード
    en
  • データソース種別
    • JaLC
    • CiNii Articles
  • 抄録ライセンスフラグ
    使用不可

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