Clinical Evaluation of Apoprotein A-I and A-II in Patients with Hepatobiliary Diseases
-
- TAKATA KOKI
- The First Department of Internal Medicine, Hiroshima University School of Medicine
-
- HINO FUMIAKI
- The First Department of Internal Medicine, Hiroshima University School of Medicine
-
- YAMAMOTO MASAHARU
- The First Department of Internal Medicine, Hiroshima University School of Medicine
-
- KAWAMOTO TOSHIO
- The First Department of Internal Medicine, Hiroshima University School of Medicine
-
- OKAHASHI MAKOTO
- The First Department of Internal Medicine, Hiroshima University School of Medicine
-
- OKI MASAMI
- The First Department of Internal Medicine, Hiroshima University School of Medicine
-
- KAJIYAMA GORO
- The First Department of Internal Medicine, Hiroshima University School of Medicine
Bibliographic Information
- Other Title
-
- 肝胆道疾患におけるアポ蛋白A-IおよびA-II測定の臨床的意義
Abstract
The serum apoproteins A-I and A-II concentrations were determined in124 patients with hepatobiliary diseases and30normal subjects.The determination of these apoproteins by single radial immunodiffusion was highly corre-ated with that by electroimmunoassay.<BR>The mass of apoproteins A-I and A-II, the major proteins of high-density lipoprotein (HDL), decreased in many liver parenChymal diseases and obstructive jaundice. But, the ratio of apoprotein A-I to A-II increased only in the decompensated stage of liver cirrhosis and obstructive jaundice-The amounts of apoproteins A-I and A-II in hepatobi-iary diseases correlated with HDL3-cholesterol (d=1.063-1.125).The clinical course of apoproteins A-I and A-II in one patient with subacute hepatitis showed the discrepancy with HDL-cholesterol, and the histological findings of biopsy specimen were identifiable with the amounts of the former than that of the latter.The amounts of apoproteins A-I and A-II correlated strognly with conventional liver functional tests (e.9., albumin, choline-esterase, total protein, lecithin-cholesterol acyltransferase).<BR>These results indicate that apoproteins A-I and A-II are metabo-ized somewhat independently of each other and the lipid components in HDL.We must, therefore, measUre apoproteins as well as lipid moieties when -ooking at patlents with hepatobiliary diseases.
Journal
-
- Japanese Journal of Clinical Chemistry
-
Japanese Journal of Clinical Chemistry 12 (4), 319-326, 1983
Japan Society of Clinical Chemistry
- Tweet
Details 詳細情報について
-
- CRID
- 1390001204912114304
-
- NII Article ID
- 130003357901
-
- ISSN
- 21874077
- 03705633
-
- Text Lang
- ja
-
- Data Source
-
- JaLC
- CiNii Articles
-
- Abstract License Flag
- Disallowed