Interleukin‐2とmitomycin C,5‐fluorouracilのリザーバー肝動注によりcomplete remissionを得た胃癌肝転移の1例


  • A Case of Complete Remission of Multiple Liver Metastases from Gastric Cancer by the Treatment of Intrahepatic Infusion of Interleukin-2(IL-2) with Mitomycin C(MMC) and 5-Fluorouracil(5-FU) Through a Subcutaneous Port.



The authors present a case of complete remission of multiple liver metastases from gastriccancer as a result of treatment by hepatic artery infusions of interleukin-2 (IL-2) with mitomycin C (MMC) and 5-fluorouracil (5-FU). A 54-year-old man, diagnosed as having extensive gastric cancer that had invaded to the lower esophagus with a solitary liver metastasis, underwent total gastrectomy, splenectomy with partial esophagectomy with regional lymph node dissection, and wedge resection of the liver. Six months after the operation, multiple liver metastases were detected by CT scanning and ultrasonography of the liver. He was readmitted and a port for hepatic arterial infusion was implanted. IL-2 combined with MMC and 5-FU was given via the hepatic artery once or twice weekly for 6 months. Judging from the CT scan and angiography taken after one month, the multiple metastatic foci noted before therapy had clearly disappeared. At the time of his last physical examination in May 1992, a liver CT scan showed no tumor recurrence.


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