骨形成不全症に依存したぼうこう浸潤Ｓ状結腸癌の１切除例

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  • A Case of Advanced Colon Cancer Associated with Osteogenesis Imperfecta.

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We report a case of advanced colon cancer with osteogenisis imperfecta. A 49-year-old woman admitted to our hospital with complaints of abdominal pain and an abdominal mass. Her height was 110 cm, and her weight was 26 kg. Endoscopic and histological examination of colon, and computed tomography revealed sigmiod colon cancer invading the bladder. We performed sigmoidectomy and partial resection of the bladder. Anesthesia was satisfactory, and no transfusions were necessary. The postoperative course was good except for atelectasis on the 2nd day after the operation. Because severe 5-fluorouracil toxicity has reported in a patient with osteogenesis imperfecta, we comfirmed that the patient had normal dehydropyrimidine dehydrogenase (DPD) activity before starting 5-FU 100mg/day orally. The patient was discharged on the 39th day after the operation, but died 19months later of liver metastasis and local recurrence in the remnant bladder. This is the first report of intestinal cancer associated with osteogenesis imperfecta.

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