Influence of the HPV16/18 Infection on the Age Distribution of Cervical Cancer Patients

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  • KARUBE Akihiro
    Dept. of Obstetrics and Gynecology, Yuri Kumiai General Hospital
  • SAITO Fumiko
    Dept. of Obstetrics and Gynecology, Yuri Kumiai General Hospital
  • NAGAO Daisuke
    Dept. of Obstetrics and Gynecology, Yuri Kumiai General Hospital
  • OTOMO Megumi
    Dept. of Obstetrics and Gynecology, Yuri Kumiai General Hospital
  • TAMURA Daisuke
    Dept. of Obstetrics and Gynecology, Yuri Kumiai General Hospital
  • KIMURA Naoko
    Dept. of Obstetrics and Gynecology, Yuri Kumiai General Hospital

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  • HPV16／18型の感染と子宮頸がんの若年発症について
  • HPV16/18ガタ ノ カンセン ト シキュウケイ ガン ノ ジャクネン ハッショウ ニ ツイテ

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Abstract

This study was conducted to document a correlation between the age distribution of patients with cervical cancers and their genotype patterns of human papilloma virus (HPV). Retrospective analysis was performed on 53 patients in the clinical stage of CIN 3 and above. The patients were treated in our hospital during the period between January 2008 and May 2011. The age distribution showed that the patients in their twenties accounted for 28.0%, those in their thirties 34.0%, those in their forties 24.0%, those in their fifties 4.0%, and those in their sixties and older 10.0%, the average of the subjects was 39.5 years. This distribution pattern also indicated that the women aged 49 and younger are prone to cervical cancer. The overall detection rate of positive HPV in the high risk group was 97.1%. The detection rates varied according to the HPV genotypes, being 41.2% in HPV16, 17.6% in HPV52, 13.2% in HPV58, and 5.9% in HPV18. The average ages of patients at the stage of CIN3 and above who demonstrated the positive and negative results for HPV16/18 were 35.4 years and 44.7 years, respectively. During the follow-up period of 40 months, 27 of 179 patients with positive HPV of the high risk group showed development of grades from below CIN2 to those CIN3 and above. Of the patients positive for HPV16/18, 30.9% demonstrated a further development of the lesions, whereas there were only 8.1% in the patients negative for HPV16/18. These studies suggested a significant connection between the viral infection of HPV16/18 and the development of cervical cancer in young women.

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