Management of Gastric Carcinoma at Aichi Cancer Center. An Audit of 4,839 Cases Treated During the Past 25 Years and Reports on the Recent Advances in Detection and Treatment of Distant Metastases.

DOI Web Site 1 Citations 5 References
  • Yamamura Yoshitaka
    Department of Gastroenterological Surgery, Aichi Cancer Center Hospital
  • Kodera Yasuhiro
    Department of Gastroenterological Surgery, Aichi Cancer Center Hospital
  • Shimizu Yasuhiro
    Department of Gastroenterological Surgery, Aichi Cancer Center Hospital
  • Torii Akihito
    Department of Gastroenterological Surgery, Aichi Cancer Center Hospital
  • Hirai Takashi
    Department of Gastroenterological Surgery, Aichi Cancer Center Hospital
  • Yasui Kenzo
    Department of Gastroenterological Surgery, Aichi Cancer Center Hospital
  • Morimoto Takeshi
    Department of Gastroenterological Surgery, Aichi Cancer Center Hospital
  • Kato Tomoyuki
    Department of Gastroenterological Surgery, Aichi Cancer Center Hospital
  • Kito Tsuyoshi
    Department of Gastroenterological Surgery, Aichi Cancer Center Hospital
  • Arai Yasuaki
    Department of Diagnostic Radiology, Aichi Cancer Center Hospital

Bibliographic Information

Other Title
  • 当院における胃癌診療の特徴　特に腹膜転移の新診断法と肝転移に対する動注化学療法

Search this article

Abstract

1) During the 30 years since the establishment of Aichi Cancer Center, there has been a marked increase in the proportion of early gastric carcinomas (especially of mucosal cancers) and a corresponding decrease in non-resectable cases. Operation was performed on 4, 839 patients during the 25 years between 1965 and 1989. These 25 years were divided into 5-year groups numbered I to V, and treatment outcome was compared according to period. An increase of 20% between groups I and V was observed in the 5-year survival rate of patients rated as curability A or B (n=3, 600). No stet difference was observed in patients rated either curability C or not resectable. The improvement in survival rate was especially prominent in 395 patients with t2 n (+) status. The improvement in outcome after surgery in patients in groups III to IV was so great that no survival benefit of adjuvant chemotherapy was observed in these groups.<BR>2) Highly sensitive detection of intraperitoneal free cells by polymerase chain reaction-mediated amplification of carcinoembryonic antigen mRNA was performed in 150 patients. Five of the 16 patients who were positive for carcinoembryonic antigen mRNA but negative by the conventional cytology examination, have been found to have peritoneal metastases thus far.<BR>3) Intra-arterial chemotherapy, consisting of 5-fluorouracil, mitomycin C, and adriamycin, through indwelling catheters was performed in 40 patients with hepatic metastases. The response rate was 72%, including 6 cases with a complete response, resulting in 50% survival of 15 months.

Journal

Citations (1)*help

See more

References(5)*help

See more

Keywords

Details 詳細情報について

Report a problem

Back to top